Suarez J, Llorente R, Romero-Zerbo SY, Mateos B, Bermudez-Silva FJ, de Fonseca FR,
Viveros MP (2009) Early maternal deprivation induces gender-dependent changes on the
expression of hippocampla CB1 and CB2 cannabinoid receptors of neonatal rats. Hippocampus
19:623– 632
Tanasescu R, Constantinescu CS (2010) Cannabinoids and the immune system: an overview.
Immunology 215:588– 597
Tyndale RF (2003) Genetics of alcohol and tobacco use in humans. Ann Med 35:94– 121
Uhl GR, Ishiguro H, Onaivi ES, Zhang PW, Akinshola BE, Lin Z, Hope B, Leonard CM, Liu Q-R
(2006) Molecular neurobiological methods in marijuana-cannabinoid research. In: Onaivi ES
(ed) Marijuana and cannabinoid research: methods and protocols. Totowa, Humana press Inc
pp 1– 17
Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N,
Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD,
Sharkey KA (2005) Identification and functional characterization of brainstem cannabinoid
CB2 receptors. Science 310:329– 332
Viscomi MT, Oddi S, Latini L, Pasquariello N, Florenzano F, Bernardi G, Molinari M,
Maccarrone M (2009) Selective CB2 receptor agonism protects central neurons from remote
axotomy-induced apoptosis through the PI3K/Akt pathway. J Neurosci 29(14):4564– 4570
Vlachou S, Panagis G (2014) Regulation of brain reward by the endocannabinoid system: a critical
review of behavioral studies in animals. Curr Pharm Des 20:2072– 2088
Yamada Y, Ando F, Shimkata H (2007) Association of candidate gene polymorphisms with
bone mineral density in community-dwelling Japanese women and men. Int J Mole Med
19:791– 801
Zhang HY, Bi GH, Li X, Li J, Qu H, Zhang SJ, Li CY, Onaivi ES, Gardner EL, Xi ZX, Liu QR
(2015) Species differences in cannabinoid receptor 2 and receptor responses to cocaine
self-administration in mice and rats. Neuropsychopharmacology 40:1037– 1051
Zhang P-W, Ishiguro H, Ohtsuki T, Hess J, Carillo F, Walther D, Onaivi ES, Arinami T, Uhl GR
(2004) Human cannabinoid receptor 1:5’exons, candidate regulatory regions, polymorphisms,
haplotypes and association with polysubstance abuse. Mol Psychiatry 9:916– 931
Zimmer A (2015) Genetic manipulation of the endocannabinoid system. In: Pertwee
(ed) Endocannabinoids, Handbook of Experimental Pharmacology. Switzerland
10 Cannabinoid CB2 Receptor Mechanism ofCannabis sativaL. 247