Thomas BF, Gilliam AF, Burch DF, Roche MJ, Seltzman HH (1998) Comparative receptor
binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther 285:285– 292
Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG (2007) Cannabidiol
displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists
in vitro. Br J Pharmacol 150:613– 623
Turner JC, Hemphill JK, Mahlberg PG (1981) Interrelationships of glandular trichomes and
cannabinoid content. I. Developing pistillate bracts ofCannabis sativaL. (Cannabaceae). Bull
Narc 33:59– 69
U.S. Drug Enforcement Administration (2015) DEA Eases Requirements for FDA-Approved
Clinical Trials on Cannabidiol. Headquarter News
Vaughan CW, Christie MJ (2005) Retrograde signalling by endocannabinoids. Handbook of
Experimental Pharmacology, pp 367– 383
Vezzani A, French J, Bartfai T, Baram TZ (2011) The role of inflammation in epilepsy. Nat Rev
Neurol 7:31– 40
Wallace MJ, Wiley JL, Martin BR, DeLorenzo RJ (2001) Assessment of the role of CB1 receptors
in cannabinoid anticonvulsant effects. Eur J Pharmacol 428:51– 57
Watanabe K, Ogi H, Nakamura S, Kayano Y, Matsunaga T, Yoshimura H, Yamamoto I (1998)
Distribution and characterization of anandamide amidohydrolase in mouse brain and liver. Life
Sci 62:1223– 1229
Watanabe K, Itokawa Y, Yamaori S, Funahashi T, Kimura T, Kaji T, Usami N, Yamamoto I
(2007) Conversion of cannabidiol toD^9 -tetrahydrocannabinol and related cannabinoids in
artificial gastric juice, and their pharmacological effects in mice. Forensic Toxicol 25:16– 21
Wiley JL, Beletskaya ID, Ng EW, Dai Z, Crocker PJ, Mahadevan A, Razdan RK, Martin BR
(2002) Resorcinol derivatives: a novel template for the development of cannabinoid CB1/CB2
and CB2-selective agonists. J Pharmacol Exp Ther 301:679– 689
Zendulka O, DovrtělováG, NoskováK, Turjap M,ŠulcováA, HanušL, Juřica J (2016)
Cannabinoids and cytochrome P450 interactions. Curr Drug Metab 17:206– 226
Zhang Y, Lipton P (1999) Cytosolic Ca2+changes during in vitro ischemia in rat hippocampal
slices: major roles for glutamate and Na+-dependent Ca2+release from mitochondria.
J Neurosci 19:3307– 3315
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