Cannabis sativa L. - Botany and Biotechnology

Table 12.1

(continued)

Location

# patients in study

Route of exposure

Clinical presentation

Allergens (molecularweights)

Reference

Milwaukee,WI (USA)

28

Smoking moldcontaminated marijuana

Mostly asymptomatic,some withbronchospasm

N/A

(Kagen et al.

1982

)

Valladolid,Spain

140 total with 53.2%patients positive forCannabis

skin prick test

and 34.3% patientspositive for speci

fic IgE

General allergic patientsand drug-dependentusers

Asthma, urticaria,rhinitis andanaphylaxis in somecases

N/A

(Armentia et al. 2011

)

Benidorm,Tres CantosandOrihuela,Spain

32 patients atopic totomato including 10 withallergic reactions toCannabis

exposure

Tomato-sensitizedpatients with contact orinhalation exposure toCannabis

Urticaria,rhinoconjunctivitis,itching and in somecases asthma-likesymptoms andpalpebral angioedema

9 –

10, 14, 30

• 35, 45

(de Larramendiet al.

2007

,^2008

)

Multi-centerstudy, Spain

44 patients tested positivefor

C. sativa

Smoking and handlingof

C. sativa

Broad respiratory andcutaneous symptomswith sporadic cases ofanaphylaxis

10 and 14 kDa(LTP) and 38 kDa(thaumatin-like protein)

(Larramendi et al. 2013

)

Toronto,Canada

17

Smoking and contactexposure. One patientconsumed marijuana tea

Rhinitis, conjunctivitis,sinusitis, wheezing,contact urticaria withperiorbital angioedemaand abdominalcramping in few cases

Major immunoreactivebands at 50 and 23identi

fied as RuBisCO

and OEP2 respectively.Other minor allergensranged from 10 to100 kDa.

(Nayak et al.

2013

;

Tessmer et al. 2012

)

Bakers

field,

CA (USA)

1

Intravenous personalexposure

Facial edema, pruritus,wheezing and dyspnea

N/A

(Perez

2000

)

(continued)

12 Allergenicity toCannabis sativaL.... 267