Systems Biology (Methods in Molecular Biology)

cancer density) or toc 3 (in our case this is non-zero corresponding to appreciable cell cancer density). The quantityc 2 plays ...

tensor) taking into account not only heterogeneity but also anisot- ropy [34] associated with the biological fibered structures ...

other hand, a nonzeromcreates a nonlinear equation for which the cancer propagation front is non-smooth. This is an interesting ...

References Thompson DW (1992) On growth and form, revised edition. Dover Publications, New York Jean RV (1994) Phyllotaxis. A s ...

Crank J (1980) The mathematics of diffusion. Oxford University Press, Oxford Jackson PR, Juliano J, Hawkins-Daarud A,·Rockne RC ...

Chapter 11 Endogenous Molecular-Cellular Network Cancer Theory: A Systems Biology Approach Gaowei Wang, Ruoshi Yuan, Xiaomei Zhu ...

1 Introduction Cancer, a popular generic term for malignant neoplasms, has been defined as an abnormal mass of tissue the growth ...

by opportunity [9]. Based on this kind of phenomena as well as others one may readily conclude that besides genome other factors ...

conclude in Subheading4 that the endogenous network theory may provide the best candidate theory to understand cancer genesis an ...

are transplantable and conserved in different organisms, for exam- ple, functional module cell cycle are conserved in different ...

can be specified by proteins and their interactions in simplifying modeling [38]. 3.Autonomous network and intrinsic stable stat ...

module may be regulated by a minimal set of molecular-cellular agents according to the accumulated molecular biology knowledge o ...

among the agents was summarized from the well-documented gene regulatory network and signaling transduction pathway that sug- ge ...

Here, Cyclin D-CDK4/6 means the concentration or activity of this protein. f(E2F, Myc, C/EBPα, p21, GSK‐ 3 β) means the integrat ...

that the relative content or activity assumptions will not affect validation, because many experimental data such as gene expres ...

Further, we test this preliminary conclusion at the molecular- cellular level. First, according to the modeling result, we summa ...

Table 2 Model result and experimental data at the molecular level Model results Experimental results HCC 1 HCC 2 HCC 3 Molecula ...

proteins in each stable state were then highlighted to reveal sub-networks that are expected to play key roles in the establish- ...

stable state could have a higher probability of undergoing gain-of- function mutations in cancers, as gain-of-function of this g ...

Table 3 Prediction of top mutated genes in cancerous hepatocyte from model Gene name Model result Cyclin D-CDK4/6 Gain-of-functi ...