Table 5
Prediction of top mutated genes in normal hepatocyte
Gene name Model result
Cyclin D-CDK4/6 Loss-of-function
Cyclin E-CDK2 Loss-of-function
Rb Gain-of-function
E2F Loss-of-function
C/EBPα Gain-of-function
Foxa2 Gain-of-function
HNF4α Gain-of-function
Fas Loss-of-function
Bcl-2/xL Loss-of-function
IAP Loss-of-function
Bax –
Bad –
Casp 9/Cytc –
Casp 8 –
Casp 3 –
E-cadherin Gain-of-function
Snail Loss-of-function
Slug Loss-of-function
Integrin Loss-of-function
Akt Loss-of-function
PTEN Gain-of-function
HIF Loss-of-function
TNFα Loss-of-function
IKK-NF-κB Loss-of-function
IKK-NF-κB (KC) Loss-of-function
IL-1 Loss-of-function
IL-6/stat Loss-of-function
EGF Loss-of-function
VEGF Loss-of-function
Ras Loss-of-function
ERK Loss-of-function
(continued)Endogenous Molecular-Cellular Network Cancer Theory 233