Precision Medicine, CRISPR, and Genome Engineering Moving from Association to Biology and Therapeutics

(Dana P.) #1
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About the Authors


Stephen H.  Tsang For years, Stephen H. Tsang has been culturing embryonic


stem (ES) cells and created the first mouse model for a recessive form of retinitis


pigmentosa by applying homologous recombination to ES cell technology. Two ele-


ments define his laboratory. First, by leveraging his genetics clinical practice, in


which over 1000 retinal patients are cared for, he brings an array of clinical resources


to his research, including stem cells and live imaging data. Second, he and his stu-


dents are recognized authorities in a broad array of state-of-the-art technologies.


Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the


Genome session during the 65th American Society of Human Genetics Annual


Meeting.


George  M. Church, professor at Harvard and MIT, coauthor of 425 papers, 95


patent publications, and the book Regenesis, developed methods used for the first


genome sequence (1994) and millionfold cost reductions since (via NGS and nano-


pores), plus barcoding, DNA assembly from chips, genome editing, writing, and


recoding. He co-initiated the BRAIN Initiative (2011) and Genome Projects (1984,



  1. to provide and interpret the world’s only open-access personal precision med-


icine datasets.

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