67Dutta B, Snyder R, Klapa MI. Significance analysis of time-series transcriptomic data: a meth-
odology that enables the identification and further exploration of the differentially expressed
genes at each time-point. Biotechnol Bioeng. 2007;98(3):668–78. doi:10.1002/bit.21432.
Dutta B, Kanani H, Quackenbush J, Klapa MI. Time-series integrated “omic” analyses to elu-
cidate short-term stress-induced responses in plant liquid cultures. Biotechnol Bioeng.
2009;102(1):264–79. doi:10.1002/Bit.22036.
Evers D, Legay S, Lamoureux D, Hausman JF, Hoffmann L, Renaut J. Towards a synthetic view of
potato cold and salt stress response by transcriptomic and proteomic analyses. Plant Mol Biol.
2012;78(4–5):503–14. doi:10.1007/s11103-012-9879-0.
Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol Biol. 2002;48(1–2):
155–71. doi:10.1007/978-94-010-0448-0_11.
Fiehn O, Kloska S, Altmann T. Integrated studies on plant biology using multiparallel techniques.
Curr Opin Biotechnol. 2001;12(1):82–6. doi:10.1016/S0958-1669(00)00165-8.
Ford CW. Accumulation of low-molecular weight solutes in water-stressed tropical legumes. Phy-
tochemistry. 1984;23(5):1007–15. doi:10.1016/S0031-9422(00)82601-1.
Gavaghan CL, Li JV, Hadfield ST, Hole S, Nicholson JK, Wilson ID, et al. Application of NMR-
based metabolomics to the investigation of salt stress in maize ( Zea mays). Phytochem Anal.
2011;22(3):214–24. doi:10.1002/pca.1268.
Geissler N, Hussin S, Koyro HW. Elevated atmospheric CO2 concentration enhances salinity tol-
erance in Aster tripolium L. Planta. 2010;231(3):583–94. doi:10.1007/s00425-009-1064-6.
Gong Q, Li P, Ma S, Indu Rupassara S, Bohnert HJ. Salinity stress adaptation competence in the
extremophile Thellungiella halophila in comparison with its relative Arabidopsis thaliana.
Plant J. 2005;44(5):826–39. doi:10.1111/j.1365-313X.2005.02587.x.
Jankangram W, Thammasirirak S, Jones MG, Hartwell J, Theerakulpisut P. Proteomic and tran-
scriptomic analysis reveals evidence for the basis of salt sensitivity in Thai jasmine rice ( Oryza
sativa L. cv. KDML 105 ). Afr J Biotechnol. 2011;10(72):16157–66. doi:10.5897/Ajb11.1559.
Jones JB. Hydroponics: a practical guide for the soilless grower. Florida: CRC Press; 2005.
Kanani HH, Klapa MI. Data correction strategy for metabolomics analysis using gas chroma-
tography-mass spectrometry. Metab Eng. 2007;9(1):39–51. doi:10.1016/j.ymben.2006.08.001.
Kanani H, Dutta B, Klapa MI. Individual vs. combinatorial effect of elevated CO2 conditions and
salinity stress on Arabidopsis thaliana liquid cultures: comparing the early molecular response
using time-series transcriptomic and metabolomic analyses. BMC Syst Biol. 2010;4:177.
doi:10.1186/1752-0509-4-177.
Kaplan F, Zhao W, Richards JT, Wheeler RM, Guy CL, Levine LH. Transcriptional and metabolic
insights into the differential physiological responses of Arabidopsis to optimal and supraopti-
mal atmospheric CO2. PLoS ONE. 2012;7(8). doi:10.1371/journal.pone.0043583.
Kim JK, Bamba T, Harada K, Fukusaki E, Kobayashi A. Time-course metabolic profiling in
Arabidopsis thaliana cell cultures after salt stress treatment. J Exp Bot. 2007;58(3):415–24.
doi:10.1093/jxb/erl216.
Klapa MI, Quackenbush J. The quest for the mechanisms of life. Biotechnol Bioeng. 2003;
84(7):739–42. doi:10.1002/bit.10858.
Legay S, Lamoureux D, Hausman JF, Hoffmann L, Evers D. Monitoring gene expression of potato
under salinity using cDNA microarrays. Plant Cell Rep. 2009;28(12):1799–816. doi:10.1007/
s00299-009-0780-5.
Li PH, Ainsworth EA, Leakey ADB, Ulanov A, Lozovaya V, Ort DR, et al. Arabidopsis transcript
and metabolite profiles: ecotype-specific responses to open-air elevated [CO(2)]. Plant Cell
Environ. 2008;31(11):1673–87. doi:10.1111/j.1365-3040.2008.01874.x.
Lu Y, Lam H, Pi E, Zhan Q, Tsai S, Wang C, et al. Comparative metabolomics in Glycine max and
Glycine soja under salt stress to reveal the phenotypes of their offspring. J Agric Food Chem.
2013;61(36):8711–21. doi:10.1021/jf402043m.
Magan JJ, Gallardo M, Thompson RB, Lorenzo P. Effects of salinity on fruit yield and quality if
tomato grown in soil-less culture greenhouses in Mediterranean climatic conditions. Agr Water
Manage. 2008;95:1041–55. doi:10.1016/j.agwat.2008.03.011.
Mahajan S, Tuteja N. Cold, salinity and drought stresses: an overview. Arch Biochem Biophys.
2005;444(2):139–58. doi:10.1016/j.abb.2005.10.018.
3 Investigating the Effect of Elevated CO 2 in the Growth Environment ...