Science - USA (2022-04-22)

PHOTO: MICHEL ROGGO/MINDEN PICTURES

SCIENCE science.org 22 APRIL 2022 • VOL 376 ISSUE 6591 327

RESEARCH

IN BRIEF

364 From Science and other journals

REVIEW

367 Metamaterials

Tunable structured light with flat optics

A. H. Dorrah and F. Capasso

REVIEW SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABI

RESEARCH ARTICLES

368 Cancer genomics

Substitution mutational signatures

in whole-genome–sequenced cancers

in the UK population

A. Degasperi et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABL

PERSPECTIVE p. 351

369 Coronavirus

Structural basis for potent

antibody neutralization of SARS-CoV-

variants including B.1.1.

T. Z h o u et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABN

370 Traffic safety

Can behavioral interventions be too salient?

Evidence from traffic safety messages

J. D. Hall and J. M. Madsen

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABM

PERSPECTIVE p. 347

371 Electrooptics

Ferroelectric crystals with giant

electro-optic property enabling

ultracompact Q-switches

X. Liu et al.

377 Cell biology

ESCRT-mediated membrane repair protects

tumor-derived cells against T cell attack

A. T. Ritter et al.

PERSPECTIVE p. 346

383 Protein design

Computational design of mechanically

coupled axle-rotor protein assemblies

A. Courbet et al.

REPORTS

390 Catalysis

Single-step hydrogen production from

NH 3 , CH 4 , and biogas in stacked proton

ceramic reactors D. Clark et al.

PERSPECTIVE p. 348

394 Cell biology

Cell division in tissues enables macrophage

infiltration M. Akhmanova et al.

397 Superconductivity

Superconducting spin smecticity evidencing

the Fulde-Ferrell-Larkin-Ovchinnikov state in

Sr 2 RuO 4 K. Kinjo et al.

PERSPECTIVE p. 350

401 Quantum sensing

Atomic-scale quantum sensing based on the

ultrafast coherence of an H 2 molecule in an

STM cavity L. Wang et al.

406 Optoelectronics

Optical absorption of interlayer excitons

in transition-metal dichalcogenide

heterostructures E. Barré et al.

410 Organic chemistry

Controlling Ni redox states by dynamic ligand

exchange for electroreductive Csp3–Csp

coupling T. B. Hamby et al.

416 Solar cells

Organometallic-functionalized interfaces

for highly efficient inverted

perovskite solar cells Z. Li et al.

420 Fisheries

Rapid evolution in salmon life history induced

by direct and indirect effects of fishing

Y. Czorlich et al.

PERSPECTIVE p. 344

ON THE COVER

A killer T cell (red) attacks an ovarian cancer

cell (white) in this digital reconstruction of

high-resolution electron micrographs. A view

into the T cell reveals the positions of its

internal structures (organelles) at the precise

moment that the T cell attempts to destroy

its target. The cancer cell, however, resists

this assault by activating a mechanism to

seal perforations in its

plasma membrane.

See pages 346 and

3 7 7. Data: Alex Ritter,

Genentech, Inc.; Gleb

Shtengel and C. Shan Xu,

Janelia Research Campus;

Rendering: Sebastian

Spaar, ariadne.ai

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CONTENTS

DEPARTMENTS

329 Editorial

Africa’s growing space enterprise

By T. Aganaba and E. Offiong

426 Working Life

Nurturing my ambitions By K. F. Boehnke

Science Staff ..............................................

Science Careers .........................................

LETTERS

361 Offshore renewables need

an experimental mindset

By A. F. Johnson et al.

361 Green energy threatens Chile’s

Magallanes Region

By H. V. Norambuena et al.

362 Brazilian pesticides law

could poison the world

By L. Carneiro et al.

344 & 420