genomes (450 from EGAS00001001178 and 80 from
EGAD00001002740). The HMF cohort can be accessed via at
http://www.hartwigmedicalfoundation.nl/en. Data access requests
and institutional agreements are required for all cohorts. The
results of the analysis can be browsed athttps://signal.
mutationalsignatures.com/explore/study/6or downloaded as a
compressed archive from Zenodo ( 44 ). The code used for this
analysis is available as Code S1 (R scripts) and Code S2 (new
version of R packagesignature.tools.libthat includes FitMS) on
Zenodo ( 45 ).
Genomics England Research Consortium
J. C. Ambrose^1 , P. Arumugam^1 , R. Bevers^1 , M. Bleda^1 , F. Boardman-Pretty1,2,
C. R. Boustred^1 , H. Brittain^1 , M. J. Caulfield1,2, G. C. Chan^1 ,
T. Fowler^1 , A. Giess^1 , A. Hamblin^1 , S. Henderson1,2,
T. J. P. Hubbard^1 , R. Jackson^1 , L. J. Jones1,2, D. Kasperaviciute1,2,
M. Kayikci^1 , A. Kousathanas^1 , L. Lahnstein^1 , S. E. A. Leigh^1 ,
I. U. S. Leong^1 , F. J. Lopez^1 , F. Maleady-Crowe^1 , M. McEntagart^1 ,
F. Minneci^1 , L. Moutsianas1,2, M. Mueller1,2, N. Murugaesu^1 ,
A. C. Need1,2,P.OÔDonovan^1 , C. A. Odhams^1 , C. Patch1,2,
D. Perez-Gil^1 , M. B. Pereira^1 , J. Pullinger^1 , T. Rahim^1 , A. Rendon^1 ,
T. Rogers^1 , K. Savage^1 , K. Sawant^1 , R. H. Scott^1 , A. Siddiq^1 ,
A. Sieghart^1 , S. C. Smith^1 , A. Sosinsky1,2, A. Stuckey^1 , M. Tanguy^1 ,
A. L. Taylor Tavares^1 , E. R. A. Thomas1,2, S. R. Thompson^1 ,
A. Tucci1,2, M. J. Welland^1 , E. Williams^1 , K. Witkowska1,2, S. M. Wood1,2(^1) Genomics England, Queen Mary University of London, Dawson
Hall, Charterhouse Square, London EC1M 6BQ, UK.^2 William Harvey
Research Institute, Queen Mary University of London, London
EC1M 6BQ, UK.
SUPPLEMENTARY MATERIALS
science.org/doi/10.1126/science.abl9283
Materials and Methods
Figs. S1 to S53
Tables S1 to S33
References ( 46 , 47 )
17 August 2021; accepted 4 March 2022
10.1126/science.abl9283
Degasperiet al.,Science 376 , eabl9283 (2022) 22 April 2022 15 of 15
RESEARCH | RESEARCH ARTICLE