has been produced by a strain ofF. solaniisolated from roots of the medicinal liana,
Coscinium fenestratum(Vinodhini and Agastian 2013 ). An endophytic fungus,
Pseudomassariasp. isolated from African rainforest was found to produce a
metabolite [L-783] which showed significant antidiabetic activity. Aspergillusol, a
compound isolated from the marine derived endophytic fungus Aspergillus
aculeatusisolated from the leaves ofCassia siamea Lam.also proved to be good
source ofa-glucosidase inhibitors in previous studies (Abdul et al. 2013 ; Ingavat
et al. 2009 ).
A number of bioactive compounds with antidiabetic potential are characteristics
of their host plant that have been isolated from endophytic fungi of different
medicinal plants (Fig.10.3). Methyl eugenol production byAlternariasp. isolated
from Rose (Kaul et al. 2008 ); phillyrin-producing endophytic fungiColletotrichum
gloeosporioides (Forsythia suspensa)(Zhang et al. 2012 ); sterigmatocystin, aru-
gosin C, and epiisoshamixanthone fromEmericella sp. (inhabiting Astragalus
lentiginosus) have shown potential antidiabetic activities (Xu et al. 2013 ). Another
example includes Helvolic acid from Xylaria sp. (Anoectochilus setaceus)
(Ratnaweera et al. 2014 ), diphenyl ether producingVerticilliumsp.(Rehmannia
glutinosa)(Ola et al. 2014 ); Dihydroanthracenone metabolites from Diaporthe
melonis (Annona squamosa) (Peng et al. 2013 ), piperine production by
Colletotrichum gloeosporioides (Piper nigrum L)(Chithra et al. 2014 ), a chromone
alkaloid such as rohitukin produced by endophytic fungi isolated fromDysoxylum
binectariferum Hook. fandAmoora rohituka (Roxb)have been reported (Kumara
et al. 2014 ).
Fig. 10.3 Antidiabetic compounds of plant origin produced by endophytes from host plant
10 Endophytes: Potential Source of Therapeutically... 225