[139] Sappakhaw K, Takasila R, Sittikul P, Wattana‐Amorn P, Assavalapsakul W, Boonyalai
N. Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand
isolates: substrate specificity and enzyme inhibition. Molecular and Biochemical
Parasitology. 2015; 204 (2):51‐63. doi:10.1016/j.molbiopara.2016.01.003
[140] Bailly E, Jambou R, Savel J, Jaureguiberry G. Plasmodium falciparum: differential sensitiv‐
ity in vitro to E‐64 (cysteine protease inhibitor) and Pepstatin A (aspartyl protease inhib‐
itor). The Journal of Protozoology. 1992; 39 (5):593‐599. doi:10.1111/j.1550‐7408.1992.
tb04856.x
[141] Andrews KT, Fairlie DP, Madala PK, Ray J, Wyatt DM, Hilton PM, et al. Potencies of
human immunodeficiency virus protease inhibitors in vitro against Plasmodium falci‐
parum and in vivo against murine malaria. Antimicrobial Agents and Chemotherapy.
2006; 50 (2):639‐648. doi:10.1128/AAC.50.2.639‐648.2006
[142] Meyers MJ, Goldberg DE. Recent advances in plasmepsin medicinal chemistry and
implications for future antimalarial drug discovery efforts. Current Topics in Medicinal
Chemistry. 2012; 12 (5):445‐455. doi:10.2174/156802612799362959
[143] Ersmark K, Samuelsson B, Hallberg A. Plasmepsins as potential targets for new antima‐
larial therapy. Medicinal Research Reviews. 2006; 26 (5):626‐666. doi:10.1002/med.20082
[144] Noteberg D, Schaal W, Hamelink E, Vrang L, Larhed M. High‐speed optimization
of inhibitors of the malarial proteases plasmepsin I and II. Journal of Combinatorial
Chemistry. 2003; 5 (4):456‐464. doi:10.1021/cc0301014
[145] Noteberg D, Hamelink E, Hulten J, Wahlgren M, Vrang L, Samuelsson B, et al. Design
and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium
falciparum‐infected cultured human erythrocytes. Journal of Medicinal Chemistry.
2003; 46 (5):734‐746. doi:10.1021/jm020951i
[146] Nezami A, Luque I, Kimura T, Kiso Y, Freire E. Identification and characterization
of allophenylnorstatine‐based inhibitors of plasmepsin II, an antimalarial target.
Biochemistry. 2002; 41 (7):2273‐2280. doi:10.1021/bi0117549
[147] Nezami A, Kimura T, Hidaka K, Kiso A, Liu J, Kiso Y, et al. High‐affinity inhibi‐
tion of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.
Biochemistry. 2003; 42 (28):8459‐8464. doi:10.1021/bi034131z
[148] Hidaka K, Kimura T, Ruben AJ, Uemura T, Kamiya M, Kiso A, et al. Antimalarial activ‐
ity enhancement in hydroxymethylcarbonyl (HMC) isostere‐based dipeptidomimetics
targeting malarial aspartic protease plasmepsin. Bioorganic & Medicinal Chemistry.
2008; 16 (23):10049‐10060. doi:10.1016/j.bmc.2008.10.011
[149] Skinner‐Adams TS, McCarthy JS, Gardiner DL, Hilton PM, Andrews KT. Antiretrovirals
as antimalarial agents. Journal of Infectious Diseases. 2004; 190 (11):1998‐2000.
doi:10.1086/425584
216 Natural Remedies in the Fight Against Parasites