Stem Cell Microenvironments and Beyond

31 Raaijmakers MH (2014) Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way? Cell Stem Cell 14: ...

32 Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM et al (2012) A phase 1/2 study of chemosensitization with t ...

© Springer International Publishing AG 2017 33 A. Birbrair (ed.), Stem Cell Microenvironments and Beyond, Advances in Experiment ...

34 4.1 Introduction Hematopoietic stem cells (HSCs) are self-renewing, multi-potent cells with the capacity to give rise to all ...

35 of HSCs then re-enter circulation and seed their final destination in the kidney mar- row (equivalent to the bone marrow in m ...

36 for the early events of hemogenic endothelial and HSC specification. Specifically, several groups demonstrated that signals a ...

37 FGF provides a precise temporal mechanism to both activate and inhibit its own signaling activity to modulate HSC formation. ...

38 mutants are loss-of-function for the meox1 gene, which encodes a homeobox factor normally expressed in the early somite. Inte ...

39 (Simard et al. 2011 ). During the first trimester of pregnancy maternal use of estro- gen hormone supplementation is associat ...

40 resent differences in receptor dimerization, downstream signaling, levels, or a com- bination of all three. In addition to VE ...

41 et al. 2014 ; He et al. 2015 ; Li et al. 2014 ; Lim et al. 2017 ; Sawamiphak et al. 2014 ; Stachura et al. 2013 ). Specifical ...

42 screen, the Zon lab found that adenosine signaling could increase HSC numbers (Tamplin et al. 2015 ) (Fig. 4.2). The elevatio ...

43 proximity of NC to emerging HSCs in the developing zebrafish suggest that short- range signaling through PDGF contributes to ...

44 et al. 2006 ). Since then, many groups have uncovered cellular constituents and vital signals regulating the stages of CHT en ...

45 30-48 hpf HSC mobilization DA CV B. A. HSC engraftment 48-72 hpf CHT AGM/DA Endotomal-derived Cell Macrophage Hemogenic Endot ...

46 mesoderm-derived stromal cells within the CHT niche. Many non-hematopoietic mesodermal cells within bone marrow are derived f ...

47 expanded pool of HSCs. Using a parabiotic zebrafish system they were able to show that Cxcr1 acts non-autonomously to promote ...

48 The preserved juxtaposition of HSCs and niche constituents from emergence through adulthood also suggests that the signals em ...

49 Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D (2010) Haematopoietic stem cells derive directly from aortic en ...

50 Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A (2009) IFNalpha activates dormant haematopoi ...