16
Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E,
Nitz K, Artinger K, Eller K et al (2017) Atypical chemokine receptor 1 on nucleated erythroid
cells regulates hematopoiesis. Nat Immunol 18:753–761
Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L,
Feng JQ et al (2013) Myelopoiesis is regulated by osteocytes through Gsalpha-dependent sig-
naling. Blood 121:930–939
Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF (2016)
Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of
stem and progenitor cells. Cell 166:894–906
Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, Madhu M, Arnett JL,
Santho RA, Dunn SK et al (2012) Connexin-43 in the osteogenic BM niche regulates its cel-
lular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.
Blood 119:5144–5154
Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T,
Link DC (2013) CXCL12 in early mesenchymal progenitors is required for haematopoietic
stem-cell maintenance. Nature 495:227–230
Hanoun M, Frenette PS (2013) This niche is a maze; an amazing niche. Cell Stem Cell 12:391–392
Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung
Y, Milo I, Poulos MG et al (2016) Distinct bone marrow blood vessels differentially regulate
haematopoiesis. Nature 532:323–328
Jones M, Chase J, Brinkmeier M, Xu J, Weinberg DN, Schira J, Friedman A, Malek S, Grembecka
J, Cierpicki T et al (2015) Ash1l controls quiescence and self-renewal potential in hematopoi-
etic stem cells. J Clin Invest 125:2007–2020
Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, Frenette PS (2006) Signals
from the sympathetic nervous system regulate hematopoietic stem cell egress from bone mar-
row. Cell 124:407–421
Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ (2005) SLAM family recep-
tors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem
cells. Cell 121:1109–1121
Kiel MJ, Radice GL, Morrison SJ (2007) Lack of evidence that hematopoietic stem cells depend on
N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell 1:204–217
Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y, Tesio M, Samstein RM,
Goichberg P, Spiegel A et al (2006) Osteoclasts degrade endosteal components and promote
mobilization of hematopoietic progenitor cells. Nat Med 12:657–664
Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas
D, Ito K et al (2013) Arteriolar niches maintain haematopoietic stem cell quiescence. Nature
502:637–643
Kusumbe AP, Ramasamy SK, Itkin T, Mae MA, Langen UH, Betsholtz C, Lapidot T, Adams RH
(2016) Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature
532:380–384
Leiva M, Quintana JA, Ligos JM, Hidalgo A (2016) Haematopoietic ESL-1 enables stem cell pro-
liferation in the bone marrow by limiting TGFbeta availability. Nat Commun 7:10222
Lymperi S, Horwood N, Marley S, Gordon MY, Cope AP, Dazzi F (2008) Strontium can increase
some osteoblasts without increasing hematopoietic stem cells. Blood 111:1173–1181
Lymperi S, Ersek A, Ferraro F, Dazzi F, Horwood NJ (2011) Inhibition of osteoclast function
reduces hematopoietic stem cell numbers in vivo. Blood 117:1540–1549
Mendez-Ferrer S, Lucas D, Battista M, Frenette PS (2008) Haematopoietic stem cell release is
regulated by circadian oscillations. Nature 452:442–447
Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT,
Ma'ayan A, Enikolopov GN, Frenette PS (2010) Mesenchymal and haematopoietic stem cells
form a unique bone marrow niche. Nature 466:829–834
D. Lucas