Organ Regeneration Based on Developmental Biology

170

Table 9.1 Genes common to iPS-derived podocytes in  vitro, human glomeruli, and mouse
podocytes in vivo

Gene

Symbol Gene name

iPS-derived

podocytes

Human

glomeruli

Mouse

podocytes

NPHS1 Nephrosis 1, congenital, Finnish type

(nephrin)

133.16 10.41 22.75

CLIC5 Chloride intracellular channel 5 120.01 6.48 9.10

NPHS2 Nephrosis 2, idiopathic, steroid resistant

(podocin)

104.25 9.99 19.95

PODXL Podocalyxin-like 77.43 9.34 26.60

CLDN5 Claudin 5 61.52 14.33 5.39

ITGA3 Integrin, alpha 3 (antigen CD49C, alpha

3 subunit of VLA-3 receptor)

54.54 9.33 9.98

CTGF Connective tissue growth factor 36.95 8.31 4.48

MAFB v-maf avian musculoaponeurotic

fibrosarcoma oncogene homolog B

27.76 14.07 8.56

FOXD1 Forkhead box D1 26.92 3.87 18.67

SEMA3G Sema domain, immunoglobulin domain

(Ig), short basic domain, secreted,

(semaphorin) 3G

23.97 31.46 6.33

WT1 Wilms tumor 1 22.01 14.02 19.15

DDN Dendrin 21.91 9.91 4.25

BCAM Basal cell adhesion molecule (Lutheran

blood group)

21.07 2.04 2.71

TCF21 Transcription factor 21 18.95 31.46 14.60

MAFB v-maf avian musculoaponeurotic

fibrosarcoma oncogene homolog B

16.09 14.07 8.56

VEGFA Vascular endothelial growth factor A 14.72 2.33 6.20

LAMA5 Laminin, alpha 5 14.05 2.27 2.32

VEGFA Vascular endothelial growth factor A 13.78 2.33 6.20

SYNPO Synaptopodin 9.62 19.26 7.40

MAGI2 Membrane-associated guanylate kinase,

WW and PDZ domain containing 2

8.37 25.02 16.28

FOXC1 Forkhead box C1 6.53 6.92 2.71

PDPN Podoplanin 6.07 8.99 17.51

MAGI2 Membrane-associated guanylate kinase,

WW and PDZ domain containing 2

4.72 25.02 16.28

LAMB2 Laminin, beta 2 (laminin S) 4.55 5.00 3.54

SYNPO Synaptopodin 4.51 19.26 7.40

MYH9 Myosin, heavy chain 9, non-muscle 4.47 4.38 4.07

LAMB2 Laminin, beta 2 (laminin S) 4.43 5.00 3.54

MYH9 Myosin, heavy chain 9, non-muscle 3.44 4.38 4.07

CD2AP CD2-associated protein 3.29 1.58 3.52

LAMC1 Laminin, gamma 1 (formerly LAMB2) 2.98 2.69 2.29

(continued)

A. Taguchi and R. Nishinakamura