Organ Regeneration Based on Developmental Biology

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A)

Periodontal tissue Regeneration

PDLSCs, DFPCs

Dentin / Pulp tissue regeneration

PDGF, bFGF, IGFs,

BDNF, ADAMTSL 6 b

Stem Cells:

DPSCs, SHED, SCAP

Molecules:

BMPs, TGF -b,NGF,

VEGF, GDNF, BDNF

Stem Cells:

Molecules:

Stem cell therapy & Cytokine approach for tooth-tissue repair

B) Tissue engineering technology for tooth-root regeneration

Porcelain-fused post crown

(Conventional dental treatment)

SCAP-loaded porous HA/TCP

PDLSCs-loaded gelfoam

Tooth crown & core restoration

Dentin regeneration

Periodontal ligament regeneration

Dental caries,

Pulp injury

Periodontal

diseases

Fig. 5.2 Tissue repair and engineering by using dental tissue-derived stem cells and cytokines.
(a) Tooth tissue-derived stem-cell transplantation and cytokine approach based on stem-cell biol-
ogy in dental field will be available for tooth-tissue repair that can achieve one of the promising
concepts in the regenerative therapy. As a regenerative approach for dental caries or pulp injury,
DPSCs, SHED and SCAP are candidate cell source for dentin repair and dental pulp regeneration.
Furthermore, the bioactive growth factors including TGF-β superfamily, IGFs, bFGF, BMPs and
various angiogenic growth factors had a potential for stimulating odontoblast-like cell differentia-
tion and dentine matrix formation. As a regenerative therapy for periodontal disease, PDLSCs and
DFSCs are thought to be useful cell types for the regeneration of periodontal tissue injury. Several
molecular approaches can be administered via the local application of human recombinant cytokines,
such as PDGF, IGFs, BDNF, bFGF and ADAMTSL6β, to accelerate periodontal regeneration

M. Oshima and T. Tsuji