140
Table 9.1
(continued)
Traverse et al. [^31
,^32
]
95
12
BMMNC
150 × 10
6
IC
AMI
MRI
Traverse et al. [
75
]
87
6
BMMNC
1.47 ± 17 × 10
8
IC
AMI
MRI
Traverse et al. [
76
]
40
6
BMMNC
1 × 10
8
IC
AMI
MRI
Tse et al. [
77
]
28
6
BMMNC
1.67 ± 0.34 × 10
7 (low),
4.20 ± 2.80 × 10
7 (High)
IM
CIHD
MRI
Turan et al. [
78
]
56
12
BMMNC
99 ± 25 × 10
6
IC
CIHD
LV G
Turan et al. [
79
]
62
12
BMMNC
9.6 ± 3.2 × 10
7
IC
AMI
LV G
Wohrle et al. [
80
,^81
]
40
36
BMMNC
381 ± 130 × 10
6
IC
AMI
MRI
Yao et al. [
82
]
47
6
BMMNC
180 × 106
IC
CIHD
MRI
Yao et al. [
83
]
39
12
BMMNC
1.9 ± 1.2 × 10
8 (single
transfusion), 2.0 ± 1.4 × 10
8
(repeat transfusion)
IC
AMI
MRI
Zhao et al. [
84
]
36
6
BMMNC
6.59 ± 5.12 × 10
8
IM w/CABG
CIHD
Echo
Modified and reproduced from Afzal et al.
Circ Res
2015;117:558–575 with permission
AMI
acute myocardial infarction,
BMC
bone marrow cells,
BMMNC
bone marrow mononuclear cells,
CABG
coronary artery bypass graft,
CIHD
chronic
ischemic heart disease,
Echo
echocardiography,
EF
ejection fraction,
Endomyo endomyocardial,
IC
intracoronary,
IM
intramuscular,
IS
infarct size,
LVG
left
ventriculography,
MI
myocardial infarction,
MRI
magnetic resonance imaging,
MSC
mesenchymal stem cells,
NA
not available,
NR
not reported,
PET
positron
emission tomography,
Transmyo
transmyocardial,
RCT
randomized controlled trial,
RNV
radionuclide ventriculography,
SPECT
single-photon emission com
Source puted tomography
Sample size
Mean follow-up duration (months)
Cell type
No. of cells transplanted
Route of injection
Type of IHD
Imaging modalities
A. Samanta et al.