Imaging in Stem Cell Transplant and Cell-based Therapy

(Nancy Kaufman) #1

140


Table 9.1

(continued)

Traverse et al. [^31

,^32

]

95

12

BMMNC

150 × 10

6

IC

AMI

MRI

Traverse et al. [

75

]

87

6

BMMNC

1.47 ± 17 × 10

8

IC

AMI

MRI

Traverse et al. [

76

]

40

6

BMMNC

1 × 10

8

IC

AMI

MRI

Tse et al. [

77

]

28

6

BMMNC

1.67 ± 0.34 × 10

7 (low),

4.20 ± 2.80 × 10

7 (High)

IM

CIHD

MRI

Turan et al. [

78

]

56

12

BMMNC

99 ± 25 × 10

6

IC

CIHD

LV G

Turan et al. [

79

]

62

12

BMMNC

9.6 ± 3.2 × 10

7

IC

AMI

LV G

Wohrle et al. [

80

,^81

]

40

36

BMMNC

381 ± 130 × 10

6

IC

AMI

MRI

Yao et al. [

82

]

47

6

BMMNC

180 × 106

IC

CIHD

MRI

Yao et al. [

83

]

39

12

BMMNC

1.9 ± 1.2 × 10

8 (single

transfusion), 2.0 ± 1.4 × 10

8

(repeat transfusion)

IC

AMI

MRI

Zhao et al. [

84

]

36

6

BMMNC

6.59 ± 5.12 × 10

8

IM w/CABG

CIHD

Echo

Modified and reproduced from Afzal et al.

Circ Res

2015;117:558–575 with permission

AMI

acute myocardial infarction,

BMC

bone marrow cells,

BMMNC

bone marrow mononuclear cells,

CABG

coronary artery bypass graft,

CIHD

chronic

ischemic heart disease,

Echo

echocardiography,

EF

ejection fraction,

Endomyo endomyocardial,

IC

intracoronary,

IM

intramuscular,

IS

infarct size,

LVG

left

ventriculography,

MI

myocardial infarction,

MRI

magnetic resonance imaging,

MSC

mesenchymal stem cells,

NA

not available,

NR

not reported,

PET

positron

emission tomography,

Transmyo

transmyocardial,

RCT

randomized controlled trial,

RNV

radionuclide ventriculography,

SPECT

single-photon emission com





Source puted tomography

Sample size

Mean follow-up duration (months)

Cell type

No. of cells transplanted

Route of injection

Type of IHD

Imaging modalities

A. Samanta et al.
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