161SCID mouse endometriosis (EM) model. Intravenous administration of therapeutic
MSCs in EM models, resulted in reduced lesion growth and angiogenesis and
exhibited impaired expression for VEGF and MMPs.
10.7.2 Myogenic Differentiation Potential of EnSCs
Menstrual blood-derived EnSCs hold high replicative ability and growth rate [ 61 ].
In vitro studies showed the myogenic differentiation potential of endometrial tissue
derived cells obtained from human menstrual blood [ 44 ]. The cells expressed mark-
ers of skeletal myogenic differentiation such as MyoD, desmin, and myogenin upon
Fig. 10.3 A comprehensive overview of the phenotypic, differentiation and immuno-phenotypic
characteristics of eutopic and ectopic MSCs. EnSCs showed positivity for expression of markers
such as CD 90, CD 44, CD 146 and PDGFRβ. Under appropriate differentiation conditions, EnSCs
differentiated to respective lineages as identified by indicated staining methods. Alizarin red stain-
ing for osteogenic and Oil-red staining for adipogenic lineages (red colour indicates lipid vacuoles
stained by Oil-Red)
10 Uterine Stem Cells and Their Future Therapeutic Potential in Regenerative Medicine