163
Table 10.2
In vivo studies and clinical trials employing human EnSCs
In vivo studiesDisease model
Mode of administration
Animal model
Outcome
References
Cardiac regeneration
DMD
Intramuscular
DMD mouse
Recovery of dystrophin expression and subsequent muscle repair
[^44
]
MI
Intra-myocardial
Nude rat
Transdifferentiation into cardiac cells and restoration of cardiac function
[^45
]
MI
Intra-myocardial
Mouse
Improvement of myocardial function
[^53
]
Neural regeneration
MI
Intravenous
Rat
Homing to the injured myocardium, tissue repair and prevention of cardiac dysfunction
[^54
]
Stroke
Intracerebral, intravenous
Rat
Significant reduction in behavioural and histological abnormalities of stroke
[^50
]
Pancreatic regeneration
Multiple sclerosis
Intraperitoneal
Mouse
Reduced EAE score; upregulated levels of anti-inflammatory cytokines
[^55
]
Parkinson’s disease
Intrastriatal
Primate
Development of neuron-like morphology; expression of tyrosine hydroxylase
[^56
]
Diabetes
Renal subcapsular injection
SCID mouse
Blood glucose levels were stabilized within 5 weeks
[^51
]
Diabetes
Renal subcapsular injection
SCID mouse
Blood insulin levels restored with prolonged survival of graft cells
[^52
]
Tissue engineering
Scaffold
Animal model
Outcome
References
Gelatin-coated polyamide knit
Rat model of wound healing
↑ Neovascularization, tissue integration, collagen fibres, distensibility of the mesh;
↓chronic inflammation, fibrosis
[^1
]
Biomimetic gelatin/apatite scaffolds
Rat model of bone regeneration
↑ Bone formation and maturation
[^57
]
(continued)
10 Uterine Stem Cells and Their Future Therapeutic Potential in Regenerative Medicine