86
- Kim IR, Murakami K, Chen NJ et al (2009)
DNA damage- and stress-induced apoptosis
occurs independently of PIDD. Apoptosis 14:
1039–1049 - Manzl C, Krumschnabel G, Bock F et al (2009)
Caspase-2 activation in the absence of
PIDDosome formation. J Cell Biol 185:
291–303 - Kumar S, Colussi PA (1999) Prodomains–adap-
tors–oligomerization: the pursuit of caspase acti-
vation in apoptosis. Trends Biochem Sci 24:1–4 - Shi Y (2004) Caspase activation, inhibition,
and reactivation: a mechanistic view. Protein
Sci 13:1979–1987 - Kumar S (1999) Mechanisms mediating cas-
pase activation in cell death. Cell Death Differ
6:1060–1066 - Schweizer A, Briand C, Grutter MG (2003)
Crystal structure of caspase-2, apical initiator of
the intrinsic apoptotic pathway. J Biol Chem
278:42441–42447 - Talanian RV, Quinlan C, Trautz S et al (1997)
Substrate specifi cities of caspase family prote-
ases. J Biol Chem 272:9677–9682 - Guo Y, Srinivasula SM, Druilhe A et al (2002)
Caspase-2 induces apoptosis by releasing pro-
apoptotic proteins from mitochondria. J Biol
Chem 277:13430–13437 - Lassus P, Opitz-Araya X, Lazebnik Y (2002)
Requirement for caspase-2 in stress-induced
apoptosis before mitochondrial permeabiliza-
tion. Science 297:1352–1354 - Robertson JD, Enoksson M, Suomela M et al
(2002) Caspase-2 acts upstream of mitochon-
dria to promote cytochrome c release during
etoposide-induced apoptosis. J Biol Chem 277:
29803–29809 - Bonzon C, Bouchier-Hayes L, Pagliari LJ et al
(2006) Caspase-2-induced apoptosis requires
bid cleavage: a physiological role for bid in heat
shock-induced death. Mol Biol Cell 17:
2150–2157 - Ho LH, Read SH, Dorstyn L et al (2008)
Caspase-2 is required for cell death induced
by cytoskeletal disruption. Oncogene 27:
3393–3404 - Dorstyn L, Puccini J, Wilson CH et al (2012)
Caspase-2 defi ciency promotes aberrant DNA-
damage response and genetic instability. Cell
Death Differ 19:1288–1298 - Shin S, Lee Y, Kim W et al (2005) Caspase-2
primes cancer cells for TRAIL-mediated apop-
tosis by processing procaspase-8. EMBO J
24:3532–3542
23. Krumschnabel G, Sohm B, Bock F et al (2009)
The enigma of caspase-2: the laymen’s view.
Cell Death Differ 16:195–207
24. Bergeron L, Perez GI, Macdonald G et al
(1998) Defects in regulation of apoptosis in
caspase-2-defi cient mice. Genes Dev 12:
1304–1314
25. O’Reilly LA, Ekert P, Harvey N et al (2002)
Caspase-2 is not required for thymocyte or
neuronal apoptosis even though cleavage of
caspase-2 is dependent on both Apaf-1 and
caspase- 9. Cell Death Differ 9:832–841
26. Nutt LK, Margolis SS, Jensen M et al (2005)
Metabolic regulation of oocyte cell death
through the CaMKII-mediated phosphoryla-
tion of caspase-2. Cell 123:89–103
27. Kumar S (2007) Caspase function in pro-
grammed cell death. Cell Death Differ 14:
32–43
28. Sidi S, Sanda T, Kennedy RD et al (2008)
Chk1 suppresses a caspase-2 apoptotic response
to DNA damage that bypasses p53, Bcl-2, and
caspase-3. Cell 133:864–877
29. Ho LH, Taylor R, Dorstyn L et al (2009) A
tumor suppressor function for caspase-2. Proc
Natl Acad Sci U S A 106:5336–5341
30. Braga M, Sinha Hikim AP, Datta S et al (2008)
Involvement of oxidative stress and caspase
2-mediated intrinsic pathway signaling in age-
related increase in muscle cell apoptosis in
mice. Apoptosis 13:822–832
31. Zhang Y, Padalecki SS, Chaudhuri AR et al
(2007) Caspase-2 defi ciency enhances aging-
related traits in mice. Mech Ageing Dev
128:213–221
32. Shalini S, Dorstyn L, Wilson C et al (2012)
Impaired antioxidant defence and accumula-
tion of oxidative stress in caspase-2-defi cient
mice. Cell Death Differ 19:1370–1380
33. Paroni G, Henderson C, Schneider C et al
(2002) Caspase-2 can trigger cytochrome C
release and apoptosis from the nucleus. J Biol
Chem 277:15147–15161
34. Bouchier-Hayes L, Oberst A, McStay GP et al
(2009) Characterization of cytoplasmic cas-
pase- 2 activation by induced proximity. Mol
Cell 35:830–840
35. Tinnikov AA, Samuels HH (2013) A novel cell
lysis approach reveals that caspase-2 rapidly
translocates from the nucleus to the cytoplasm
in response to apoptotic stimuli. PLoS One
8:e61085
36. Thornberry NA, Rano TA, Peterson EP et al
(1997) A combinatorial approach defi nes
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