Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

EFFECTS ON IMMUNE RESPONSE 97

Table 5.1. Select Characteristics of T and B Cells

T Cells

B Cells

Cell of origin

Hematopoietic stem cell

Site of maturation

Thymus

Bursa Fabricius (birds);bone marrow (mammals)

Function

Regulatory (help, suppression) and

Precursor of antibody-

effector (delayed-type hypersensitivity,

producing cell

mixed lymphocyte reaction, cytotoxic or “ killer”)

Primary anatomic localization

— Spleen

Periarteriolar cuff

Follicles

— Lymph node

Para-cortex

Primary follicles

— Peyer’s patch

Interfollicular

Follicles

Recirculating pool

Majority (80-85% in mouse)

Minority (15-20% in mouse)

Life span

4-6 months

6-8 weeks

Mitogenic response

PHA, Con A

LPSPurified protein derivative

Memory

Yes

Source:

After Anderson et al.11