Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

110 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES

Figure 5.13. Response of irradiated spleen cells to optimal concentrations of PH A, Con
A, pokeweed mitogen (PWM), and LPS. Results are given as a percentage
of the corresponding control (0 rad) values (broken line). Adapted from
Anderson and Troup.24

tion of growth (and tumorigenesis) or those involved in definition of “self”

(and thus autoreactivity). This line of thinking suggests that it is in the

host’s best interests to do away with irradiated lymphocytes as quickly

(interphase) and as efficiently (apoptosis) as possible.

Of these possibilities, the third is clearly the most attractive, in part because
it is susceptible to testing experimentally.

REFERENCES

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3. Kennedy, J. C., J. E. Till, L. Simonovitch, and E. A. McCullough. “Radiosen­
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4. Janeway, C. A. “Cellular Cooperation During In Vivo Antihapten Antibody
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