Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

150 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES

covalent binding of, 62, 63
enhancement of toxicity of, 63
metabolism of, 62
Carcinogenesis, 113-117. See also
Cancer
Carcinogens, 114
Catechin (cyanidanol), 83
Cell adaptation, 113-117
Cell death, 98
Cell defense mechanisms, 59
Cell differentiation, 98, 106, 114
Cell division, 42, 68, 70, 73-79, 105
Cell dysdifferentiation, 5, 10
Cell proliferation, 81
Cell regeneration, 60, 69, 70, 71, 73
Chlordecone, 61, 64-67, 70, 73, 74
hormesis nonexpression and, 75-76
two-stage toxicity model and, 79, 82,
83, 84
Chlorinated pesticides, 61. See also
specific types
Chloroform, 15, 28, 29, 62
Cholesterol, 10
Cholesterol-lowering drugs, 10. See
also specific types
Chromatin, 45, 46
Chromosomal proteins, 46
Circadian rhythm, 54-55
Coincidence, 107-109
Colchicine, 78-79, 81
Collapsing, 14
Competitive advantage, 109
Competitive exclusion, 5
Complex chemical waste mixtures, 63
Concanavalin A, 105
Conditional mortality rate. See Hazard
function
Cortisone, 47
Cosmic radiation. See Gamma
radiation
Covalent binding, 62
Crowding, 15
Cyanidanol (catechin), 83
Cyanide, 41
Cysteamine, 63
Cysteine, 63
Cytochrome P-450, 61, 62, 63, 66, 71,
75, 77, 83

Cytoprotective mechanisms, 60

Cytotoxicity, 60. See also Toxicity

DDT, 15, 29, 31, 63

Death cells, 98

Defense mechanisms, 59, 69. See also

specific types

Demethylation, 45

Deprenyl (selegiline), 9

Deterioration, 5

Developmental defects, 47

Diazepam, 47

Dieldrin, 15, 27

Dietary modification, 9. See also

specific types

Differentiation, 98, 106, 114

Dinitrophenol, 43

Division of cells, 42, 68, 70, 73-79,

105

DNA damage response, 46-47

DNA-damaging agents, 44-46. See also

specific types

DNA methylation, 45

DNA repair, 45, 53-56

DNA repair agents, 45. See also

specific types

DNA replication, 44

DNA viruses, 114

Dosage

low. See Low doses

of radiation, 32

threshold, 59, 84-85

toxicity and, 59

Dose-dependent effect, 16

Dose-response relationships, 13, 59,

104

for Halomethanes. See Halomethane

hepatotoxicity

qualitative risk-benefit evaluation

and, 119-137

meta-analysis and, 134-137

standardized ratios and, 125-134

two-by-two tables and, 120-125

quantitative models of, 137-142

Doxylamine, 55

Drosophila spp. (fruit flies), 4, 43, 44,

47

Dysdifferentiation, 5, 10