Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

152 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES

Hepatotoxicity of halomethane. See
Halomethane hepatotoxicity
Hexachlorobenzene, 15, 29, 30
Hill equation (logarithmic-logistic
function), 13
Histochemical studies, 66
Histomorphometric studies, 66, 71
Histone, 45
Homeostasis, 12
Homogeneity, 6
Hormesis, 59, 60
ablation of, 75
biochemical mechanisms in, 61
defined, 3, 41
early-phase, 76-79
evolution of, 60
generic concept of, 3
growth, 3
in halomethane hepatotoxicity. See
Halomethane hepatotoxicity
longevity. See Longevity hormesis
meta-analytic studies of, 134-137
nonexpression of, 75-76
stress protein response in, 41-48
Hormetic agents, 41-43, 47. See also
specific types
Hsp 70, 43-44, 46
Hydrogen peroxide, 45
Hyperbolic function, generalized
(logarithmic-logistic function), 13
Hypermethylation, 55
Hypotheses, 4. See also specific types
on allometric scaling principles,
10-12
defined, 3
description of specific, 5-14
on hazard function, 6
on instability, 12-13
on linear Gompertz function, 6-7
on longevity hormesis, 8-9, 13-14
on senescence, 5, 7-10
on toxicity, 5-6

Immune response, 5, 59, 85, 95-110

auto-, 106, 109-110

cellular components of, 96

coincidence and, 107-109

competitive advantage and, 109

slow decay of, 95

suppression of, 101

Insecticides, 41. See also specific types

Instability, 12-13

Instantaneous mortality rate. See

Hazard function

Internal healthy worker effect, 32

Interphase cell death, 98

Interspecies extrapolation, 23

Introns, 46

Ionizing radiation, 8, 30, 41, 46, 85,

101

Irradiation. See Radiation

Isoleucine, 45

Kepone. See Chlordecone

Ketones, 63. See also specific types

Least squares analysis, 3, 18

Lidocaine, 44

Life spans, 42, 54

Linear Gompertz function, 6-7, 8, 13,

14, 16, 17, 19, 28

Linear least squares analysis, 3

Linear multistage models, 140-141

Lipid peroxidation, 61, 62, 66, 68, 69

Lipids, 44. See also specific types

Lipopolysaccharides, 105, 110. See also

specific types

Local anesthetics, 44. See also specific

types

Logarithmic-logistic function, 13

Longevity hormesis, 1, 3, 4, 9, 12-13

authenticated data on, 16-29

database for, 4, 14-15

defined, 4, 13

description of, 4, 8

elimination of, 16

gender specificity of, 17

hypotheses on, 8-9, 13-14

problems in assessment of in

humans, 29-32

steady-state, 17

Low doses

qualitative risk-benefit evaluation

and, 119-137

meta-analytic methods and,

134-137

standardized ratios and, 125-134

two-by-two tables and, 120-125