Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

HYPOTHESES ON LONGEVITY HORMESIS 31

Figure 1.21. Gompertz plots for control and DDT-treated female CF-1 mice. DDT

administration (2-250 ppm feed) was begun at 6-7 weeks of age and

continued throughout life. Time on the abscissa refers to that period

following initiation of dosing. The 2-ppm curve-fit is virtually superimposed

on that of controls. Although the data are consistent with concomitant

longevity hormesis and toxicity, and this model was used in the curve-fits,

the figure is equivocal in making a more definitive judgment. The

theoretical lines were obtained by simultaneous fitting of Equations 3 and

12, employing weighted least-squares regression analysis. Both 7 and X

were characterized by a logarithmic-logistic function. The original data

came from Tomatis et al.101 Reprinted from Neafsey et al.,25 p. 143, by

permission of Marcel Dekker, Inc.

Figure 1.22. Gompertz plots for control and DDT-treated male CF-1 mice. DDT
administration (2-250 ppm feed) was begun at 6-7 weeks of age and
continued throughout life. Time on the abscissa refers to that period
following initiation of dosing. Although the data are consistent with
concomitant longevity hormesis and toxicity, and this model was used in
the curve-fits, the figure is equivocal in making a more definitive judgment.
The theoretical lines were obtained by simultaneous fitting of Equations 3
and 12, employing weighted least-squares regression analysis. Both 7 and
X were characterized by a logarithmic-logistic function. The original data
came from Tomatis et al.101 Reprinted from Neafsey et al.,25 p. 146, by
permission of Marcel Dekker, Inc.