Holford, N. H. G., and L. B. Sheiner. “Pharmacokinetic and Pharmacody
namic Modeling in vivo,” CRC Crit. Rev. Bioeng. 5:273-322 (1981).
Holford, N. H. G., and L. B. Sheiner. “Kinetics of Pharmacologic Response,”
Pharmacol. Ther. 16:143-166 (1982).
Kenakin, T. P. Pharmacologic Analysis of Drug-Receptor Interaction (New
York: Raven Press, 1987).
Levitzki, A. Receptors: A Quantitative Approach (Menlo Park, CA: The
Benjamin/Cummings Pub. Co., 1984).
Riggs, D. S. The Mathematical Approach to Physiological Problems (Balti
more: The Williams and Wilkins Co., 1963), Chapter 11, pp. 272-298.
Tallarida, R. J., and L. S. Jacob. The Dose-Response Relation in Pharmacol
ogy (New York: Springer-Verlag, 1979).
Wagner, J. G. “Kinetics of Pharmacologic Response. I. Proposed Relation
ships between Response and Drug Concentration in the Intact Animal and
Man,” J. Theor. Biol. 20:173-201 (1968).
Wagner, J. G. “Aspects of Pharmacokinetics and Biopharmaceutics in Rela
tion to Drug Activity,” Am. J. Pharm. 141:5-20 (1969).
Wagner, J. G. “Relations between Drug Concentration and Response,” J.
Mond. Pharm. 4:279-310 (1971).
Boxenbaum, H. G., S. Riegelman, and R. M. Elashoff. “Statistical Estima
tions in Pharmacokinetics,” J. Pharmacokin. Biopharm. 2:123-148 (1974).
Heidrick, M. L., L. C. Hendricks, and D. E. Cook. “Effect of Dietary 2-
Mercaptoethanol on the Life Span, Immune System, Tumor Incidence and
Lipid Peroxidation Damage in Spleen Lymphocytes of Aging BC3F1 Mice,”
Mech. Ageing Dev. 27:341-358 (1984).
Skalicky, M., H. Bubna-Littitz, and G. Hofecker. “The Influence of Persistent
Crowding on the Age Changes of Behavioral Parameters and Survival Charac
teristics of Rats,” Mech. Aging Dev. 28:325-336 (1984).
Sacher, G. A. “Effects of X-Rays on the Survival of Drosophila Imagoes,”
Physiol. Zool. 36:295-311 (1963).
Paracelsus. “Seven Defensiones: The Reply to Certain Calumniations of His
Enemies,” C. L. Temkin (translator), in Four Treatises of Theophrastus von
Hohenheim called Paracelsus, H. E. Sigerist, Ed. (Baltimore: The Johns
Hopkins Press, 1941), pp. 1-41.
Daniel, C., and F. S. Wood. Fitting Equations to Data, 2nd ed. (New York:
John Wiley and Sons, 1980).
Brownlee, K. A. Statistical Theory and Methodology in Science and Engineer
ing (New York: Wiley, 1960), pp. 306-307.
Yu, B. P., E. J. Masoro, and C. A. McMahan. “Nutritional Influences on
Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteris
tics,” J. Gerontol. 40:657-670 (1985).
Lorenz, E., J. W. Hollcroft, E. Miller, C. C. Congdon, and R. Schweisthal.
“Long-Term Effects of Acute and Chronic Irradiation in Mice. I. Survival and
Tumor Incidence Following Chronic Irradiation of 0.11 r per Day,” J. Nat.
Cane. Inst. 15:1049-1058 (1955).
Lorenz, E., L. O. Jacobson, W. E. Heston, M. Shimkin, A. B. Eschenbrenner,
M. K. Deringer, J. Doniger, and R. Schweisthal. “Effects of Long-Continued
Total-Body Gamma Irradiation on Mice, Guinea Pigs, and Rabbits. III.
Effects of Life Span, Weight, Blood Picture, and Carcinogenesis and the Role
