Drug Metabolism in Drug Design and Development Basic Concepts and Practice
should be based on the pervious PK studies. The total study time should cover at least three to five the plasma half-life (t1/2) ...
from time 0 to the last time point (AUC0–t), and area under the concentration– time curve from 0 to infinity (AUC0– 1 ), are cal ...
TABLE 18.A2 Estimated pharmacokinetic parameters used to calculate radiation absorbed from selected tissues in male Long–Evansra ...
AUC0– 1 is obtained from the rat pharmacokinetic data, and the test article specific activity is derived from analysis of the do ...
The effective dose equivalent in man in millirem (mrem) is calculated using the following equation: Radiation absorbed doseðmRad ...
Beumer JH, Beijnen JH, Schellens JHM. Mass balance studies, with a focus on anticancer drugs. Clin Pharmacokinet 2006;45(1):33–5 ...
Owellen RJ, Hartke CA, Hains FO. Pharmocokinetics and metabolism of Vinblastine in humans. Cancer Res 1977;37:2597–2602. Rickert ...
Index Accelerated or mass spectrometry (AMS), 301, 597 Accurate mass measurement, 342, 584 Accurate radioisotope counting (ARC), ...
Central nervous system (CNS), 149 Cerebrospinal fluid (CSF), 149 Chloramphenicol acetyl transferase (CAT), 559 Collision-induced ...
First-pass metabolism, 252 Fish-odor syndrome, 21 Flavin-containing monooxygenase (FMO), 16, 20, 481, 485 Flow scintillation ana ...
Mass analyzers, 325 329 beam-type, 325 ion-trapping, 325 Mass balance, 586 Mass defect filter (MDF), 346, 348, 584 Mechanism-bas ...
Radiometric assays, 65 Reaction phenotyping, 477 N-acetylation reaction phenotyping, 487 Nonradiolabeled reaction phenotyping, 4 ...
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