Drug Metabolism in Drug Design and Development Basic Concepts and Practice

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Cl

NO 2

NO 2

GST
GSH

NO 2

NO 2

SG Cl

Cl-

SG

NO 2

NO 2

1-Chloro-2,4-dinitrobenzene
(CDNB)


Intermediate σ -complex

O

CYP1A2

Styrene Styrene oxide

O 2 , NADPH

GST
GSH

OH

S-G

FIGURE 3.9 Two typical reactions catalyzed by GSTs.

84 CONJUGATIVE METABOLISM OF DRUGS

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