TABLE 6.3 (
Continued
)
Substrate
Inhibitor
Inducer
Result
Possible interacting protein
Reference
Fluvastatin
Cyclosporin A
Increase in AUC
(1.9-fold)
Goldberg and Roth (1996)
Glipizide
Rifampin Decrease in AUC
(
22%) and
Cmax
(+18%), Decreasein
t1/2
(
35%)
P-gp, CYP2C9
Niemi et al. (2001)
Glyburide
Rifampin Decrease in AUC
(
39%) and
Cmax
(
22%), Decrease
in
t1/2
(
17%)
P-gp, CYP2C9
Niemi et al. (2001)
Indinavir
St. John’s
wort
Decrease in AUC
(
57%) and
Cmax
(12.3
!
8.9), no
change in
t1/2
P-gp, CYP3A4
Piscitelli et al. (2000)
Irinotecan
(CPT11)
Huangqin
significant improvement
in diarrhea grades(P
= 0.044) as well
as a reduced frequencyof diarrheagrades 3 and 4
Multiple factors, one
of them could bedue to modulation
of P-gp
Mori et al. (2003)
Losartan
Grapefruit juice
Increase in
AUC (+17%)
P-gp, CYP3A4
Zaidenstein et al. (2001)
Loperamide
Quinidine(600 mg/m
2 )
Increase in AUC
(2.5-fold), expressionof respiratorydepression
P-pg
Sadeque et al. (2000b)
166