Drug Metabolism in Drug Design and Development Basic Concepts and Practice

TABLE 6.3

(Continued

)

Substrate

Inhibitor

Inducer

Result

Possible interacting protein

Reference

Taxol

(Paclitaxel)

Verapamil



Decrease in

clearance (



50%)

P-gp, CYP3A4

Berg et al. (1995)

Topotecan

GF120918



Increase in

AUC (2.4-fold, po)

BCRP and P-gp

Kruijtzer et al. (2002)

Vincristine

Nifedipine



Increase in

AUC (3.4-fold)

P-gp, CYP3A4

Fedeli et al. (1989)

170