Drug Metabolism in Drug Design and Development Basic Concepts and Practice

(nextflipdebug2) #1

Ieiri I, Suzuki H, Kimura M, Takane H, Nishizato Y, Irie S, Urae A, Kawabata K,
Higuchi S, Otsubo K, Sugiyama Y. Influence of common variants in the
pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels
in healthy subjects. Hepatology Res 2004;30:91–95.
Ishizuka H, Konno K, Shiina T, Naganuma H, Nishimura K, Ito K, Suzuki H,
Sugiyama Y. Species differences in the transport activity for organic anions across
the bile canalicular membrane. J Pharmacol Exp Ther 1999;290:1324–1330.
Jalava KM, Partanen J, Neuvonen PJ. Itraconazole decreases renal clearance of
digoxin. Ther Drug Monit 1997;19:609–613.
Johne A, Brockmoller J, Bauer S, Maurer A, Langheinrich M, Roots I.
Pharmacokinetic interaction of digoxin with an herbal extract from St John’s wort
(Hypericum perforatum). Clin Pharmacol Ther 1999;66:338–345.
Johne A, Schmider J, Brockmoller J, Stadelmann AM, Stormer E, Bauer S, Scholler G,
Langheinrich M, Roots I. Decreased plasma levels of amitriptyline and its metabolites
on comedication with an extract from St. John’s wort (Hypericum perforatum). J Clin
Psychopharmacol 2002;22:46–54.
Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JHM,
Schinkel AH. Role of breast cancer resistance protein in the bioavailability and fetal
penetration of topotecan. J Nat Cancer Inst 2000;92:1651–1656.
Jonker JW, Merino G, Musters S, van Herwaarden AE, Bolscher E, Wagenaar E,
Mesman E, Dale TC, Schinkel AH. The breast cancer resistance protein BCRP
(ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med
2005;11:127–129.
Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese
hamster ovary cell mutants. Biochim Biophys Acta Biomembr 1976; 455:152–162.
Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza
EC, Adachi Y. Recent advances in bilirubin metabolism research: the molecular
mechanism of hepatocyte bilirubin transport and its clinical relevance.
J Gastroenterol 2000;35:659–664.
Kantola T, Kivisto KT, Neuvonen PJ. Erythromycin and verapamil considerably
increase serum simvastatin and simvastatin acid concentrations. Clin Pharmacol
Ther (St. Louis) 1998;64:177–182.
Kaplan B, Meier-Kriesche HU, Napoli KL, Kahan BD. The effects of relative timing of
sirolimus and cyclosporine microemulsion formulation coadministration on the
pharmacokinetics of each agent. Clin Pharmacol Ther 1998;63:48–53.
Kaukonen K-M, Olkkola KT, Neuvonen PJ. Itraconazole increases plasma concentra-
tions of quinidine. Clin Pharmacol Ther (St. Louis) 1997;62:510–517.
Kemp DC, Zamek-Gliszczynski MJ, Brouwer KLR. Xenobiotics inhibit hepatic uptake
and biliary excretion of taurocholate in rat hepatocytes. Toxicol Sci 2005;83:207–214.
Keppler D, Jedlitschky G, Leier I. Transport function and substrate specificity of
multidrug resistance protein. Methods Enzymol 1998;292:607–616.
Kerb R. Implications of genetic polymorphisms in drug transporters for pharma-
cotherapy. Cancer Lett (Amsterdam, Netherlands) 2006;234:4–33.
Kerr DJ, Graham J, Cummings J, Morrison JG, Thompson GG, Brodie MJ, Kaye SB.
The effect of verapamil on the pharmacokinetics of adriamycin. Cancer Chemother
Pharmacol 1986;18:239–242.


REFERENCES 191

Free download pdf