renal insufficiency: first case presentation showing competition for excretion via renal
multidrug resistance protein 1 and organic cation transporter 2. Clin Pharmacol Ther
2006;79:389–396.
van der Heijden J, de Jong MC, Dijkmans BAC, Lems WF, Oerlemans R, Kathmann I,
Schalkwijk CG, Scheffer GI, Scheper RJ, Jansen G. Development of sulfasalazine
resistance in human T cells induces expression of the multidrug resistance transporter
ABCG2 (BCRP) and augmented production of TNFa. Ann Rheum Dis
2004a;63:138–143.
van der Heijden J, de Jong MC, Dijkmans BAC, Lems WF, Oerlemans R, Kathmann I,
Scheffer GI, Scheper RJ, Assaraf YG, Jansen G. Acquired resistance of human T
cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-
related DMARDs. Ann Rheum Dis 2004b;63:131–137.
van Zuylen L, Verweij J, Nooter K, Brouwer E, Stoter G, Sparreboom A. Role of
intestinal P-glycoprotein in the plasma and fecal disposition of docetaxel in humans.
Clin Cancer Res 2000;6:2598–2603.
Velpandian T, Jasuja R, Bhardwaj RK, Jaiswal J, Gupta SK. Piperine in food: interference in
the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokine 2001;26:241–248.
Volk EL, Schneider E. Wild type breast cancer resistance protein (BCRP/ABCG2) is a
methotrexate polyglutamate transporter. Cancer Res 2003;63:5538–5543.
Wakasugi H, Yano I, Ito T, Hashida T, Futami T, Nohara R, Sasayama S, Inui K.
Effect of clarithromycin on renal excretion of digoxin: interaction with P-
glycoprotein. Clin Pharmacol Ther 1998;64:123–128.
Wang E-J, Casciano CN, Clement RP, Johnson WW.In vitroflow cytometry method to
quantitatively assess inhibitors of P-glycoprotein.Drug Metab Dispos 2000;28:522–528.
Wang E-j, Casciano CN, Clement RP, Johnson WW. Fluorescent substrates of sister-P-
glycoprotein (BSEP) evaluated as markers of active transport and inhibition:
evidence for contingent unequal binding sites. Pharm Res 2003;20:537–544.
Wang Z, Hamman MA, Huang S-M, Lesko LJ, Hall SD. Effect of St John’s wort on the
pharmacokinetics of fexofenadine. Clin Pharmacol Ther (St. Louis, MO, United
States) 2002;71:414–420.
Wattel E, Solary E, Hecquet B, Caillot D, Ifrah N, Brion A, Mahe B, Milpied N,
Janvier M, Guerci A, Rochant H, Cordonnier C, Dreyfus F, Buzyn A, Hoang-Ngoc
L, Stoppa AM, Gratecos N, Sadoun A, Stamatoulas A, Tilly H, Brice P, Maloisel F,
Lioure B, Desablens B, Pignon B, Abgrall JP, Leporrier M, Dupriez B, Guyotat D,
Lepelley P, Fenaux P. Quinine improves the results of intensive chemotherapy in
myelodysplastic syndromes expressing P glycoprotein: results of a randomized study.
Br J Haematol 1998;102:1015–1024.
Wattel E, Solary E, Hecquet B, Caillot D, Ifrah N, Brion A, Milpied N, Janvier M,
Guerci A, Rochant H, Cordonnier C, Dreyfus F, Veil A, Hoang-Ngoc L, Stoppa
AM, Gratecos N, Sadoun A, Tilly H, Brice P, Lioure B, Desablens B, Pignon B,
Abgrall JP, Leporrier M, Dupriez B, Guyotat D, Lepelley P, Fenaux P. Quinine
improves results of intensive chemotherapy (IC) in myelodysplastic syndromes
(MDS) expressing P-glycoprotein (PGP): updated results of a randomized study.
Adv Exp Med Biol 1999;457:35–46.
Weller S, Blum MR, Doucette M, Burnette T, Cederberg DM, Miranda Pd, Smiley ML.
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and
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