The nonclinical species used in the ADME studies are based on toxicology
species used in the long-term safety evaluation of the compound. These are
typically rodent (rat and mouse) and nonrodent (rabbit, dog or monkey)
species. The study is designed to closely mimic the toxicology studies keeping
the dose selected, the route of administration, and the dosing vehicle as close as
possible to those used in the actual studies. The amount of radioactive dose
administered in animal species is usually determined by the pharmacokinetic
FIGURE 9.2 An example of quantitiative whole body autoradiography (QWBA) in rat
after administration of C-14-labeled material. The figure shows the distribution
of radioactivity at various time points postdose. The image was generated by
taking a sliced section of the whole body of rat and exposing it to a phosphorimaging film.
IN VIVOADME STUDIES 269