TABLE 11.1 (
Continued
)
Metabolic reactionDescriptionMolecular formulachangem
/zchangeR–CO–R0!R–CHOH–R0Ketone to alcohol+H22.0157R–CH–R 20!R–C(O)–R0Methylene to ketone–H+ O 213.9792Hydroxylation and desaturationHydroxylation and desaturation–H+ O 213.9792R–XH!R–X–CH3
(X = N, O, S)N, O, S methylation+CH214.0157R–CHCH 23
!R–COOHEthyl to carboxylic acid–CH+O 4215.9586R–H!R–OHHydroxylation+O15.9949R–NH–R0!R–NOH–R0 ;RR0 RN!RR0 R0 NOSecond/third amine tohydroxylamine/N
-oxide+O15.9949R–S–R0!R–SO–R0 ; R–SO–R0!R–(O)S(O)–R0Thioether to sulfoxide,sulfoxide to sulfone+O15.9949R–CH = CH–R0!R–CH(O)CH–R0Aromatic ring to areneoxide+O15.9949R–CHCH 23
!R–CH–(OH)2Demethylation and twohydroxylation–CH+O 2217.9741R–CH = CH–R!R–CH–CHOH–R 20Hydration, hydrolysis(internal)+HO 218.0106R–CN!R–CONH2Hydrolysis of aromaticnitriles+HO 218.0106Hydroxylation and ketone formationHydroxylation and ketoneformation–H+O 2229.9741CHnm!CHnm-2O2Quinine formation–H+O 2229.9741R–CH! 3R–COOHMethyl to carboxylation–H+O 2229.9741R–H!R–O–CH3Hydroxylation andmethylation+CHO 230.01052hydroxylation2hydroxylation+O231.9898RR0 S!RR0 SO2Thioether to sulfone+O231.9898R–CH = CH–R0!R–CH(OH)–CH(OH)–R0Alkenes to dihydrodiols+HO 2
234.0054R–NH! 2R–NHCOCH3Acetylation+CH 2O 242.01063hydroxylation3hydroxylation+O347.9847R–SH!R–SOH 3Aromatic thiols tosulfonic acids+O347.9847(continued)
333