Drug Metabolism in Drug Design and Development Basic Concepts and Practice

TABLE 11.1 (

Continued

)

Metabolic reaction

Description

Molecular formulachange

m

/z

change

R–COOH

!

R–CO–SG (GSH = Glutathione)

S-Acyl-glutathione

conjugates

+C

10

H

15

N

O 3

S 5

289.0732

+GSH–4H

Desaturation + GSH

+C

10

H

13

N

O 3

S 6

303.0525

+GSH–2H

GSH conjugation

+C

10

H

15

N

O 3

S 6

305.0682

+GSH

GSH conjugation

+C

10

H

17

N

O 3

S 6

307.0839

+GSH + O–2H

Oxidation + GSH

conjugation

+C

10

H

15

N

O 3

S 7

321.0631

Epoxidation + GSH

Epoxidation + GSH

conjugation

+C

10

H

17

N

O 3

S 7

323.0788

+2

C

H 6

O 8

6

2

glucuronide conjugation

+C

12

H

16

O

12

352.0642

Adapted with modification from with permission of the American Chemical Society.

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