Drug Metabolism in Drug Design and Development Basic Concepts and Practice

(nextflipdebug2) #1

Grossman, SJ. Are most toxicities caused by reactive metabolites? In: Molecular
Toxicology, Josephy PD, Mannervik AB, editors. New York: Oxford University
Press; 2006. p 373–374.
Miller EC, Miller JA. Biochemical investigations on hepatic carcinogenesis. J Natl
Cancer Inst 1955;15(5 Suppl):1571–1590.
Murphy MP, Beaman ME, Clark LS, Cayouette M, Benson L, Morris DM, Polli JW.
Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a
phase III clinical trial. Pharmacogenetics 2000;10(7):583–590.
Mutlib AE, Gerson RJ, Meunier PC, Haley PJ, Chen H, Gan LS, Davies MH,
Gemzik B, Christ DD, Krahn DF, Markwalder JA, Seitz SP, Robertson RT,
Miwa GT. The species-dependent metabolism of efavirenz produces a nephrotoxic
glutathione conjugate in rats. Toxicol Appl Pharmacol 2000;169(1):102–113.


REFERENCES 13

Free download pdf