Guengerich FP. Metabolic activation of carcinogens. Pharmacol Ther 1992;54:17–61.
Guengerich FP. Common and uncommon cytochrome P450 reactions related to
metabolism and chemical toxicity. Chem Res Toxicol 2001;14:611–650.
Halliwell B, Whiteman M. Measuring reactive species and oxidative damagein vivoand
in cell culture: how should you do it and what do the results mean? Br J Pharmacol
2004;142:231–255.
Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative
stress in atherosclerosis. Am J Cardiol 2003;91(3A):7A–11A.
Ho B, Castagnoli N. Trapping of metabolically generated electrophilic species with
cyanide ion: metabolism of 1-benzylpyrrolidine. J Med Chem 1980;23:133–139.
Iskander K, Jaiswal AK. Quinone oxidoreductases in protection against myelogenous
hyperplasia and benzene toxicity. Chem Biol Interact 2005;153–154:147–157.
James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug
Metab Dispos 2003;31:1499–1506.
Kalgutkar AS, Dalvie DK, O^0 Donnell JP, Taylor TJ, Sahakian C. On the diversity of
oxidative bioactivation reactions on nitrogen-containing xenobiotics. Curr Drug
Metab 2002;3:379–424.
Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE,
Dalvie DK, Lee JS, Nakai Y, O’Donnell JP, Boer J, Harriman SP. A comprehensive
listing of bioactivation pathways of organic functional groups. Curr Drug Metab
2005;6:161–225.
Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Ann Rev
Pharmacol Toxicol 2004;44:239–267.
Koenigs LL, Peter RM, Hunter AP, Haining RL, Rettie AE, Friedberg T, Pritchard
MP, Shou M, Rushmore TH, Trager WF. Electrospray ionization mass spectro-
metric analysis of intact cytochrome P450:identification of tienilic acid adducts to
P450 2C9. Biochemistry 1999;38:2312–2319.
Liebler DC, Guengerich FP. Elucidating mechanisms of drug-induced toxicity. Nat Rev
Drug Discov 2005;4:410–420.
Loughlin AF, Skiles GL, Alberts DW, Schaefer WH. An ion exchange liquid
chromatography/mass spectrometry method for the determination of reduced and
oxidized glutathione and glutathione conjugates in hepatocytes. J Pharm Biomed
Anal 2001;26:131–142.
Meneses-Lorente G, Sakatis MZ, Schulz-Utermoehl T, De Nardi C, Watt A. A
quantitative high-throughput trapping assay as a measurement of potentialfor
bioactivation. Anal Biochem 2006;351:266–272.
Miller EC, Miller JA. Mechanisms of chemical carcinogenesis. Cancer 1981;47(5 S):
1055–1064.
Muller L, Kikuchi Y, Probst G, Schechtman, L, Shimada, H, Sofuni, T, Tweats, D.
ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution,
reasoning and impact. Mutat Res 1999;436:195–225.
O’Brien PJ. Molecular mechanisms of quinone cytotoxicity. Chem Biol Interact
1991;80:1–41.
Olsen J, Li C, Bjornsdottir I, Sidenius U, Hansen SH, Benet LZ.In vitroandin vivo
studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chem Res
Toxicol 2005;18:1729–1736.
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