Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. The role of
metabolic activation in drug-induced hepatotoxicity. Annu Rev Pharmacol Toxicol
2005;45:177–202.
Parkinson A. Biotransformation of xenobiotics. In: Klaassen, CD, editor. Casarett &
Doull’s Toxicology: The Basic Sciences of Poisons. New York: McGraw-Hill
Companies; 2001. p 133–224.
Pereg D, Robertson LW, Gupta RC. DNA adduction by polychlorinated biphenyls:
adducts derived from hepatic microsomal activation and from synthetic metabolites.
Chem Biol Interact 2002;139:129–144.
Ritter JK. Role of glucuronidation and UDP-glucuronosyltransferase in xenobiotic
bioactivation reactions. Chem Biol Interact 2000;129:171–193.
Sallustio BC, Harkin LA, Mann MC, Krivickas SJ, Burcham PC. Genotoxicity of acyl
glucuronide metabolites formed from clofibric acid and gemfibrozil: a novel role for
phase II-mediated bioactivation in the hepatocarcinogenicity of the parent
aglycones? Toxicol Appl Pharmacol 1997;147:459–464.
Sallustio BC, DeGraaf YC, Weekley JS, Burcham PC. Bioactivation of carboxylic acid
compounds by UGT-glucuronosyltransferase to DNA-damaging intermediates: role
of glycoxidation and oxidative stress in genotoxicity. Chem Res Toxicol
2006;19:683–691.
Shipkova M, Armstrong VW, Oellerich M, Wieland E. Acyl glucuronide drug
metabolites: toxicological and analytical implication. Therap Drug Metab2003;
25:1–6.
Smith MT, Evans CG, Thor H, Orrenius S. Quinone-induced oxidative injury to cells
and tissues. In: Sies H, editor. Oxidative Stress.Orlando, FL: Academic Press Inc;
- p 91–113.
Soglia JR, Harriman SP, Zhao S, Barberia J, Cole MJ, Boyd JG, Contillo LG. The
development of a higher throughput reactive intermediate screening assay
incorporating micro-bore liquid chromatography–micro-electrospray ionization–
tandem mass spectrometry and glutathione ethyl ester as anin vitroconjugating
agent. J Pharm Biomed Anal 2004;36:105–116.
Svardal AM, Mansoor MA, Ueland PM. Determination of reduced, oxidized,
and protein-bound glutathione in human plasma with precolumn derivatization
with monobromobimane and liquid chromatography. Anal Biochem 1990;184:
338–346.
Tang W, Miller RR. In vitro drug metabolism: thiol conjugation. In:Yan Z, Caldwell
GW, editors. Methods in Pharmacology and Toxicology Optimization in Drug
Discovery:In VitroMethods. Totowa, NJ: Human Press Inc; 2005. p 369–383.
Uetrecht J. New concepts in immunology relevant to idiosyncratic drug reactions: the
‘‘danger hypothesis’’ and innate immune system. Chem Res Toxicol 1999;12:387–
Walgren JL, Mitchell MD, Thompson. Role of metabolism in drug-induced
idiosyncratic hepatotoxicity. Crit Rev Toxicol 2005;35:325–361.
Wang J, Davis M, Li F, Azam F, Scatina J, Talaat R. A novel approach for predicting
acyl glucuronide reactivity via Schiff base formation: development of rapidly formed
peptide adducts for LC/MS/MS measurements. Chem Res Toxicol. 2004;17:1206–
REFERENCES 475