Drug Metabolism in Drug Design and Development Basic Concepts and Practice

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duodenum (Vietri et al., 2000). The dietary flavonoid quercetin inhibits
metabolism of dopamine, minoxidil, salbutamol, acetaminophen, and apo-
morphine (Marchetti et al., 2001; Vietri et al., 2002). Apomorphine and
salbutamol sulfonation is additionally inhibited by mefenamic acid. Salicylic
acid and apomorphine are known to interact in a similar fashion (Vietri et al.,
2000; Vietri et al., 2002).


FIGURE 3.7 Detection of sulfonated conjugates with mass spectrometry. Adopted
from Shima et al., J Chromatog B Analyt Technol Biomed life Sci 2005 Oct 28,
epub.


CYTOSOLIC SULFOTRANSFERASES 69

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