Hartmann, M., Ernst, S. (2000), Selective oxidations of linear alkanes with molecular oxygen on mole-
cular sieve catalysts – a breakthrough?,Angew. Chem. Int. Ed. 39 , 888–890.
Hasemann, C. A., Ravichandran, K. G., Peterson, J. A., Deisenhofer, J. (1994), Crystal structure and
refinement of cytochrome P450terp at 2.3 A ̊resolution,J. Mol. Biol. 236 , 1169–1185.
Hedegaard, J., Gunsalus, I. C. (1965), Mixed function oxidation. IV. An induced methylene hydroxylase in
camphor oxidation,J. Biol. Chem. 240 , 4038–4043.
Henke, E., Bornscheuer, U. T. (1999), Directed evolution of an esterase fromPseudomonas fluorescens.
Random mutagenesis by error-prone PCR or a mutator strain and identification of mutants showing
enhanced enantioselectivity by a resorufin-based fluorescence assay,Biol. Chem. 380 , 1029–1033.
Hercule, H. C., Oyekan, A. O. (2000), Cytochrome P450x/x-1 hydroxylase-derived eicosanoids con-
tribute to Endothelin(A) and Endothelin(B) receptor-mediated vasoconstriction to Endothelin-1 in the
rat preglomerular arteriole,J. Pharmacol. Exp. Ther. 292 , 1153–1160.
Hoch, U., Zhang, Z., Kroetz, D. L., Ortiz de Montellano, P. R. (2000), Structural determination of the
substrate specificities and regioselectivities of the rat and human fatty acidx-hydroxylases,Arch.
Biochem. Biophys. 373 , 63–71.
Holton, T. A. (1995), Modification of flower colour via manipulation of P450 gene expression in trans-
genic plants,Drug Metab. Drug Interact. 12 , 359–368.
Holton, T. A., Brugliera, F., Lester, D. R., Tanaka, Y., Hyland, C. D., Menting, J. G., Lu, C. Y., Farcy, E.,
Stevenson, T. W., Cornish, E. C. (1993), Cloning and expression of cytochrome P450 genes controlling
flower colour,Nature 366 , 276–279.
Hosny, G., Roman, L. J., Mostafa, M. H., Masters, B. S. (1999), Unique properties of purified,Escherichia
coli-expressed constitutive cytochrome P4504A5,Arch. Biochem. Biophys. 366 , 199–206.
Imaoka, S., Ogawa, H., Kimura, S., Gonzalez, F. J. (1993), Complete cDNA sequence and cDNA-directed
expression of CYP4A11, a fatty acidx-hydroxylase expressed in human kidney,DNA Cell. Biol. 12 ,
893–899.
Johnson, R. A. (1978), in: Oxidation in Organic Synthesis; (Trahanowsky, W.S., Ed.), Vol. Part C, pp. 131.
New York: Academic Press.
Joo, H., Arisawa, A., Lin, Z., Arnold, F. H. (1999a), A high-throughput digital imaging screen for the
discovery and directed evolution of oxygenases,Chem. Biol. 6 , 699–706.
Joo, H., Lin, Z., Arnold, F. H. (1999b), Laboratory evolution of peroxide-mediated cytochrome P450
hydroxylation,Nature 399 , 670–673.
Juchau, M. R. (1990), Substrate specificities and functions of the P450 cytochromes,Life Sci. 47 , 2385–
2394.
Juchau, M. R., Boutelet-Bochan, H., Huang, Y. (1998), Cytochrome-P450-dependent biotransformation
of xenobiotics in human and rodent embryonic tissues,Drug Metab. Rev. 30 , 541–568.
Kaim, W., Schwederski, B. Ed. (1995), Bioanorganische Chemie, Vol. 2, Stuttgart: Teuber.
Karuzina, I., Archakov, A. I. (1994), Hydrogen peroxide-mediated inactivation of microsomal cyto-
chrome P450 during monooxygenase reactions,Free Radical Biol. Med. 17 , 557–567.
Kieslich, K. (1980), in:Biotechnology, 1st Edn.; (Rehm, H.-J., Reed, G.; Ed.), Vol. 6a, pp. 1. Weinheim:
Verlag Chemie.
Kisselev, P., Wessel, R., Pisch, S., Bornscheuer, U., Schmid, R. D., Schwarz, D. (1998), Branched phos-
phatidylcholines stimulate activity of cytochrome P450SCC (CYP11A1) in phospholipid vesicles by
enhancing cholesterol binding, membrane incorporation, and protein exchange,J. Biol. Chem. 273 ,
1380–1386.
Kuhn-Velten, W. N. (1997), Effects of compatible solutes on mammalian cytochrome P450 stability,Z.
Naturforsch. 52 , 132–135.
Kulprecha, S., Ueda, T., Nihira, T., Yoshida, T., Taguchi, H. (1985), Optimum conditions for ursodeoxy-
cholic acid production from lithocholic acid byFusarium equisetiM41,Appl. Environ. Microbiol. 49 ,
338–344.
Kupfer, D. (1980), Endogenous substrates of monooxygenases: fatty acids and prostaglandins,Pharma-
col. Ther. 11 , 469–496.
Kupfer, D., Holm, K. A. (1989), Prostaglandin metabolism by hepatic cytochrome P-450,Drug Metab.
Rev. 20 , 753–764.
Lewis, D. F. (1998), The CYP2 family: models, mutants and interactions,Xenobiotica 28 , 617–661.
Lewis, D. F. (1999), Homology modelling of human cytochromes P450 involved in xenobiotic metabo-
lism and rationalization of substrate selectivity,Exp. Toxicol. Pathol. 51 , 369–374.
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