- Phosphorylation Data Analysis 83
Figure 6. Visualization of overlap between enriched GO terms.- Specify a query condition. By default, DynaPho collects proteins which
phosphorylation level are changed at least in one of time points. Users
can focus on the proteins at a specific time point and uses these proteins
as seeds to construct the network of each time point. - Click on “Submit” to get to the result page.
- Inspect dynamic network analysis results. DynaPho provides two modes
to view the networks: “proteins with phosphorylation sites” and “protein
only” (Fig. 8). In “protein only” mode, the color of protein is based on
the maximum phosphorylation change of the corresponding phosphosites.
To view the transition of networks, DynaPho will fix the structure of the
network, and users can change the time point or condition by dragging
the slider bar (Fig. 9).
Kinase activity analysis
One of the major challenges in phosphoproteomics analysis is to identify
the key kinases associated with the experimental conditions. The kinase