84 A Practical Guide to Cancer Systems Biology
Figure 7. Visualization of function profile in DynaPho. The color of the cell indicates
level of significance (darker = more significant).
activity profile is generated by integrating phosphosite residue with flanking
sequences and phosphorylation profiles. This profile can reveal the activity
of kinase at each time point or condition.
- Click on “Kinase activity” on the header.
- Set a criterion for defining the phosphosites with differential change on
phosphorylation. - Set a p-value cutoff to determine the kinase with significant activity
change. - Click on “Submit” to get to the result page.
- Inspect kinase activity profile. The profile is visualized as a heatmap
(Fig. 10). The kinases with similar profiles will be clustered. In the
profile, the red and blue cells denote the kinases have significant