- Phosphorylation Data Analysis 87
Figure 10. Visualization of kinase activity profile. The color of the cell indicates level of
significance (darker = more significant) where blue and red are significant activation and
inactivation and grey is no significance.
activation and inactivation at the given time point, respectively. The
hierarchical clustering will be performed, and kinases with similar profiles
will be clustered together. The consensus motif of a kinase will be show
by dragging mouse on the row of this kinase.Kinase/phosphatase–phosphosite association network
Kinase/phosphatase–substrate association is the basic component of the
signaling transduction. To associate kinases or phosphatase with substrates
identified in the form of individual phosphorylation sites, DynaPho applies a
correlation-based method, which calculate the phosphorylation correlations
to infer these associations.^9
- Click on “Correlation analysis” on the header.
- Specify the parameters for correlation analysis. The kinase/phosphatase–
phosphosite association network is constructed by a correlation-based
method. To determine the relationship between kinase/phosphatase and