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“6x9” b2861 The Cell Language Theory: Connecting Mind and Matter

upper right-hand corner of Figure 3.35). Hence, to completely understand

how the F 0 F 1 –ATP synthase works, it would be necessary to know how

these three types of catalyses take place.

Table 3.3 compares the three categories of enzyme catalyses, showing

both their differences (see the second and third columns) and their similari-

ties (see the last column). Since the “pre-fit” mechanism (see Section 3.2.9),

which contrasts with Koshland’s “induced-fit” mechanism [28] widely

accepted in biochemistry textbooks, is thought to be common, if we under-

stand how this mechanism is manifested in simpler enzyme systems, the

Figure 3.9 A proposed mechanism of enzyme catalysis based on the GFCP. Reproduced

from [14, p. 26]. Conformons are defined as localized conformational strains of bio-

polymers (see Section 3.4). A generalized molecular mechanism of enzymic catalysis based

on the conformon postulate. The y-axis represents the Gibbs free energy changes accompa-

nying the progression of the enzymic reaction. The x-axis indicates the reaction coordinate,

R, which is a function of the nuclear positions of all the atoms affected by the reaction. The

active site is assumed to be lined with four different amino acid residues designated 1, 2, 3,

and 4. The shapes of the substrate and the product are geometrically complementary to the

shapes of the interacting amino acid residues. For more details, see text.

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