Cell Language Theory, The: Connecting Mind And Matter

The Bhopalator 113

“6x9” b2861 The Cell Language Theory: Connecting Mind and Matter

Figure 3.28 Mitochondria as the mediator and regulator of cellular response to stress trans-

mitted by stress hormones, glucocorticoids, catecholamines, and cytokines [199–201].

Wallace and coworkers [201] recently showed the possible role that

mitochondria may play in mediating and modulating the cellular

response to environmental stress experienced by whole organism. They

reviewed extensive experimental evidence indicating that mitochondria

may mediate the cellular response to environmental stresses. For exam-

ple, mutating or deleting mitochondrial genes ND6 (encoding NADH

dehydrogenase 6) and CO1 (encoding cytochrome c oxidase subunit 1)

was found to affect the response patterns of mice to restraint stress

monitored as (i) the hypothalamic–pituitary–adrenal axis (HPA) activa-

tion, (ii) sympathetic adrenal medullary (SAM) activation, (iii) the

blood levels of catecholamines, the inflammatory cytokine IL-6, and

circulating metabolites, and (iv) hippocampal gene expression profiles.

These observations led Wallace et al. to conclude that

b2861_Ch-03.indd 113 17-10-2017 11:46:35 AM