Cell Language Theory, The: Connecting Mind And Matter

The Bhopalator 121

“6x9” b2861 The Cell Language Theory: Connecting Mind and Matter

Figure 3.31 A proposed mechanism of conformon transfer from one enzyme system to

another based on the principle of electrogenic relaxation of charge separated state with

complementary charge flows in its environment. Reproduced from [6].

It is possible to transfer conformons from a donor to an acceptor if the

donor and the acceptor can interact electrostatically while preserving

the electroneutrality, i.e., producing no net increase or decrease in

electric charges. (3.38)

The elastic energy transfer from the g-subunit to the b-subunits of the

F 1 F 0 –ATPase that is postulated by Wang and Oster [163, 204], by Nath

[151, 161], and in the Rochester–Noji–Helsinki mechanism of oxphos

(see Figure 3.35) can all be effectuated at the molecular level by the CTM

detailed in Figure 3.31.

The ATP hydrolysis-driven unidirectional rotation of the g-subunit of

the F 1 F 0 –ATP synthase directly observed by Noji and Yoshida in 2001 (see

Figure 3.41) [205] may also implicate the mechanical/elastic/conforma-

tional energy transfer from F 1 to the g-subunit, most likely mediated by

conformons a la Figure 3.31 as explained below.

One possible mechanism for transferring conformons from one enzyme

system to another involves the requirement that the electrogenic relaxation

of the charge-separated state of an enzyme system occurs if and only if

accompanied by complementary charge flows in its environment, as sche-

matically depicted in Figure 3.31. What is not shown in Figure 3.31 is the

transition state in which the conformationally contracted double-circle sys-

tem is partially relaxed (or stretched) and the double-hexagon system is

partially contracted through Brownian motions so that two protons can be

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