Cell Language Theory, The: Connecting Mind And Matter

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“6x9” b2861 The Cell Language Theory: Connecting Mind and Matter

synthase do not participate in the chemistry of ATP synthesis in F 1 (as

claimed in Figure 3.32(b)), but these two processes, i.e., the proton flow

through F 0 and ATP synthesis in F 1 , are coupled through the g-subunit that

transmits the torsional (also called mechanical or conformational) strains

(i.e., conformons discussed in Section 3.4) generated by the proton-driven

rotary motions of F 0 to the rotary propagation of the conformational waves

in the a 3 b 3 portion of F 1 which catalyzes the phosphorylation of ADP and

de-binding of ATP (see Figure 3.36).

The quantitative aspect of the chemiosmotic model summarized as

Feature (5) seems largely invalidated, as well since (i) the H+/2e- stoichi-

ometry is about 4 for coupling sites 1, 2, and 3 [118, 162, 177] and not 2

and (ii) H+/ATP stoichiometry is 8/3 = 2.7 in animals and 10/3 = 3.33 in

yeast [240] and not 2. In other words, according to the chemiosmotic

model, these two stoichiometries must be equal, H+/2e- = H+/ATP, but in

fact they are not, which agree with the conformon model of oxphos,

according to which the H+/2e- = n depends on the relative rates of step 2

(intramembrane proton transfer) and step 3 (trans-membrane proton trans-

fer) (see Figure 3.29), while H+/3ATP = m is fixed by the number of pro-

ton binding sites on the F 0 component of F 1 F 0 –ATP synthase which

Figure 3.33 The F 1 F 0 -ATP synthase on the plasma membranes of tumor, endothelial, and

liver cells. Reproduced from [207].

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