Cell Language Theory, The: Connecting Mind And Matter

298 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

that TR would be a simple linear function of TL, but as can be seen here,

TR is clearly not linearly related to TL in about half of the time. (The com-

ponents of the TL–TR trajectories that are parallel to a straight line with a

slope of about 1 indicate linear correlations between TL and TR.)

Experimental evidence indicates that TL is determined by the balance

of two opposing processes — the transcription of genes into RNA or

mRNA (i.e., TR) and the degradation of mRNA into shorter fragments

(whose rate is denoted as TD, transcript degradation rates) [548], so that

the following relation holds:

d(aTL)/dt = b(TR) – c(TD) (7.7)

where a, b, and c are the parameters whose magnitude may or may not

depend on individual mRNA nucleotide sequences. If we assume that a

Figure 7.5 Plots of fold changes in TR and TL of budding yeast during metabolic transi-

tions caused by glucose–galactose shift. These four examples (for mRNA molecules

encoded in genes #1, #3, #10, and #19) were chosen randomly out of the 5184 mRNA

molecules investigated by Perez-Ortin and his coworkers [315]. Fold change in TL,

denoted by fTL, is defined as the ratio of TL at time t over the TL at t = 0, i.e., fTL = TL/

TL 0. Each plot shows the results of six measurements at t = 0, 5, 120, 360, 450, and 850

min after glucose was replaced with galactose in the growth medium.

fTL-fTR Plot 1

0

0.2

0.4

0.6

0.8

1

1.2

00 .5 11 .5

Fold Changes in TL

Fol

d Ch

ange

s in

TR

fTL-fTR Plot 3

0

0.2

0.4

0.6

0.8

1

1.2

0246

6

6

1

Fold Changes in TL

Fol

d Ch

anges in

TR

fTL-fTR Plot 10

0

0.2

0.4

0.6

0.8

1

1.2

0123

Fold changes in TL

Fol

d Ch

ange

s in

TR 1

6

fTL-fTR 19

0

0.5

1

1.5

2

00 .5 11 .5

Fold Changes in TL

Fol

d Ch

an

ges in

TR^1

6

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