Cell Language Theory, The: Connecting Mind And Matter

300 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

concepts are also discussed by Srere (“metabolons” [323]), Hartwell et al.

(“modules” [190]), and Lehn (“supramolecular chemistry” [324]).

The rich information contained in the TR and TL data measured by

Garcia-Martinez et al. [315] can be more fully displayed in a three-

dimensional space consisting of the TR, TD, and TL axes (Figure 7.6). The

TD data were calculated from fTL and fTR data using Eq. (7.8). For this

purpose, the dfTL/dt at any time point was computed by differentiating the

approximate TL function derived from TL data by an nth-degree polynomial

fitting procedure, where n is the number of measuring time points, i.e., 6.

One of the most striking features of the TR–TD–TL plots is that,

despite major changes in the TR and TD values, the TL values often

remain relatively constant. This may suggest that, during the metabolic

perturbations caused by glucose–galactose shift, the yeast cell manages to

Figure 7.6 The three-dimensional plots sowing the dependence of the mRNA levels (TL)

on the rates of transcription (TR) (denoted as tr) and mRNA degradation (TD) (denoted as

v3). The vertical lines indicate the TL values plotted on the z-axis. Each plot shows the

identity of the gene encoding the mRNA under observation. These mRNA molecules

(coded by genes 1, 5, 6, and 8) are arbitrarily selected out of about 6000 mRNA molecules

investigated in [315]. (I thank Drs. Sunil Dhar and Robert Miura, both of NJIT, for their

help in preparing the plots shown in this figure.)

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