Cell Language Theory, The: Connecting Mind And Matter

Applications of the Cell Language Theory to Biomedical Sciences 319

“6x9” b2861 The Cell Language Theory: Connecting Mind and Matter

six groups of RNA levels analyzed with PDE, only one pathway, i.e., the

CD pathway, showed statistically significant changes in all the three PDE

parameter values induced by doxorubicin treatment. It is interesting to

note that the statistically significant drug effects on the MAPK pathway

are captured in the b/A ratios, while those on the ETF pathway were cap-

tured in the B/A ratios of PDE. Thus, it may be concluded that,

Of the 5 metabolic pathways examined, the cluster of differentiation

proteins may be most intimately connected with breast cancer. (7.26)

The 20 breast cancer patients in Table 7.2 were divided into three

groups — (i) short survivors (8–17 months), (ii) intermediate survivors

(22–57 months), and (iii) long survivors (66–89 months). The RNA levels

of the short and long survivors before (BE) and after (AF) treating with

doxorubicin were used to generate long-tailed histograms, some examples

of which are being shown in Figure 7.17. The numerical values of the

Figure 7.17 Some examples of human breast cancer microarray histograms fitting PDE.

The mechanisms and the number of ORFs graphed are indicated along with the informa-

tion about drug treatment.

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012345

frequency

mRNA bins

mRNA histogram

(Mechanism 6, BE, 171 ORFs, 5 short survivors)

Experimental

PDE

-2

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0123456

frequency

mRNA bins

mRNA histogram

(Mechanism 6, AF, 176 ORFs, 5 short survivors)

Experimental

PDE

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0246

frequency

mRNA bins

mRNA histogram

(Mechanism 8, BE, 1164 ORFs, 5 short survivors)

Experimental

PDE

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0123456

frequency

mRNA bins

mRNA histogram

(Mechanism 8, AF, 1212 ORFs, short survivors)

Experimental

PDE

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