Cell Language Theory, The: Connecting Mind And Matter

328 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

cancer patients (Figures 7.20 and 7.22), the positive slope of the graphs

indicating beneficial effects of the drug-induced RNA phenotypes and the

negative slope indicating the harmful effects.

7.3.4 The PDE-Based Approach to Discovering Dissipative Structure

(or Dissipaton)- Targeting Drugs

The basic premise underlying the PDE-based approach to drug discovery

that I have been advocating since 2012 [25, p. 618] and described below

is that dissipative structures (or dissipatons) (Section 2.6) are the ultimate

targets of drugs in contrast to the traditional view which regards equilib-

rium structures (equilibrons) as drug targets. The idea of dissipaton-

targeting drugs (DTDs) can be expressed in several equivalent ways:

The ultimate targets of all drugs are the dissipative structures of the

living cell or ic-dissipatons. (7.28)

where ic stands for “intracellular”.

No therapeutic nor toxic effects can be exerted by any agent without

affecting cell functions or ic-dissipatons. (7.29)

It is impossible for an agent to be therapeutically effective unless it can

affect cell functions, i.e., ic-dissipatons. (7.30)

Statements (7.28)–(7.30) were referred to as the First Law of Therag-

nostics in 2012 [25, p. 618].

Figure 7.23 summarizes the key steps involved in the PDE-based analy-

sis of ribonoscopic data for drug discovery research. The method of prepar-

ing the samples from which RNA levels are measured using microarrays is

described in Figure 7.10. During drug discovery phase, the samples N, BE,

and AF are required. For personalized medicine, AF samples must be

replaced with AF’ samples to identify the most efficacious drugs from a set

of available candidate drugs for individual patients [25, pp. 607–20]. The

difference between AF and AF’ is that the former represents the mRNA data

measured from tumor tissues of a group (numbering 10–50?) of test cancer

patients treated with experimental drugs, whereas AF’ represents the

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